The germinal center: a crucible for lymphocyte selection.
The germinal center: a crucible for lymphocyte selection.
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DOI：
10.1006/smim.1996.0022
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发表时间：
1996-06-01
影响因子：
7.8
通讯作者：
Kelsoe, G
中科院分区：
文献类型：
--
作者：
Kelsoe, G
抗原首先激活次级淋巴组织 T 细胞区域中的 T 和 B 淋巴细胞，其中同源和共刺激依赖性增殖扩大了反应性淋巴细胞的数量。从该群体中选择的 T 细胞和 B 细胞后代迁移到 B 细胞区域，形成生发中心 (GC)，在此发生强烈的增殖、凋亡和 V(D)J 超突变。现在已知，这些过程中的每一个都发生在 GC 淋巴细胞的两个区室中，并且 GC T 细胞代表了 αβ T 辅助细胞的一个不寻常的 Thy-1- 子集，它可能代表了随着 GC 反应结束而丢失的终末分化细胞。
Antigen first activates T and B lymphocytes in the T-cell areas of secondary lymphoid tissues where cognate- and costimulus-dependent proliferation expands the population of reactive lymphocytes. Selected T- and B-cell progeny from this population migrate into B-cell zones to form germinal centers (GC), where intense proliferation, apoptosis, and V(D)J hypermutation takes place. It is now known that each of these processes occur in both compartments of GC lymphocytes and that the GC T-cell represents an unusual Thy-1- subset of alpha beta T-helper cells that may represent a terminally differentiated cell that is lost with the end of the GC reaction.