Reward-predicting and reward-detecting neuronal activity in the primate supplementary eye field
Reward-predicting and reward-detecting neuronal activity in the primate supplementary eye field
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DOI：
10.1152/jn.2000.84.4.2166
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发表时间：
2000-10-01
影响因子：
2.5
通讯作者：
Schlag, J
中科院分区：
文献类型：
--
作者：
Amador, N;Schlag-Rey, M;Schlag, J
除了对视觉刺激、眼跳或注视特别活跃的细胞外，补充眼区还包含与奖励发生精确时间关系的细胞。我们研究了奖励相关的活动，在两只猴子进行正面/反正面任务，在一只猴子训练的记忆正面。两种类型的神经元区分其相互放电模式：奖励预测（RP）和奖励检测（RD）。RP神经元线性增加他们的射击早在150毫秒前扫视发作，直到奖励的发生，在这个时候，他们突然停止射击。相反，RD神经元与奖励传递同步，即使其持续时间不同，并且以不同的频率重复。RD放电的影响很小或不受影响的视觉线索，短暂锚定的目标在发病奖励的位置。RP和RD神经元的互补放电模式可以提供学习和执行任务所需的反馈机制。
In addition to cells specifically active with visual stimuli, saccades, or fixation, the supplementary eye field contains cells that fire in precise temporal relationship with the occurrence of reward. We studied reward-related activity in two monkeys performing a prosaccade/antisaccade task and in one monkey trained in memory prosaccades only. Two types of neurons were distinguished by their reciprocal firing pattern: reward-predicting (RP) and reward-detecting (RD). RP neurons linearly increased their firing as early as 150 ms before saccade onset until the occurrence of reward, at which time they abruptly ceased firing. In contrast, RD neurons fired in phase with reward delivery, even when its duration was varied and when it was repeated at different frequencies. RD discharges were little affected or unaffected by the position of a visual cue that briefly anchored the goal at the onset of reward. The complementary firing patterns of the RP and RD neurons could provide a feedback mechanism necessary for learning and performing the task.