Repeatability and contingency in the evolution of a key innovation in phage lambda.
Repeatability and contingency in the evolution of a key innovation in phage lambda.
复制标题
DOI：
10.1126/science.1214449
复制
发表时间：
2012-01-27
期刊：
影响因子：
--
通讯作者：
Lenski RE
中科院分区：
文献类型：
--
作者：
Meyer JR;Dobias DT;Weitz JS;Barrick JE;Quick RT;Lenski RE
The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological opportunities, remain poorly understood. We examined how a virus, bacteriophage λ, evolved to infect its host, Escherichia coli, through a novel pathway. Natural selection promoted the fixation of mutations in the virus’s host-recognition protein, J, that improved fitness on the original receptor, LamB, and set the stage for other mutations that allowed infection through a new receptor, OmpF. These viral mutations arose only after the host evolved reduced expression of LamB, whereas certain other host mutations prevented the phage from evolving the new function. This study shows the complex interplay between genomic processes and ecological conditions that favor the emergence of evolutionary innovations.
登录
查看更多内容
DOI：
10.1007/bf00270887
发表时间：
1978-01-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
BRAUNBRETON, C;HOFNUNG, M
通讯作者：
HOFNUNG, M
大肠杆菌K-12的构造框架，单基因敲除突变体：Keio Collection。
影响因子：
9.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.0703274104
发表时间：
2007-09-11
影响因子：
11.1
作者：
Grayson, Paul;Han, Lin;Phillips, Rob
通讯作者：
Phillips, Rob
影响因子：
2.9
作者：
Berkane, E;Orlik, F;Benz, R
通讯作者：
Benz, R
影响因子：
3.2
作者：
Cooper, VS;Schneider, D;Lenski, RE
通讯作者：
Lenski, RE