Suppression of apoptotic cell death by hepatitis C virus core protein
Suppression of apoptotic cell death by hepatitis C virus core protein
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DOI：
10.1006/viro.1996.0644
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发表时间：
1996-12-15
期刊：
影响因子：
3.7
通讯作者：
Ray, R
中科院分区：
文献类型：
--
作者：
Ray, RB;Meyer, K;Ray, R
我们先前已经证明了丙型肝炎病毒（HCV）核心蛋白在细胞和无关病毒启动子的转录调控中的作用。此外，核心蛋白与H-ras癌基因合作将原代大鼠胚胎成纤维细胞转化为致瘤表型。在本研究中，研究了HCV核心蛋白的功能作用，以确定其抑制凋亡细胞死亡的潜力。HCV核心蛋白表达抑制顺铂介导的人宫颈上皮细胞凋亡和c-myc过表达诱导的中国仓鼠卵巢细胞凋亡。从这些研究结果表明，核心蛋白可能有生物学意义的HCV感染的发病机制。(C)出版社：Academic Press Inc.
We have previously demonstrated the role of hepatitis C virus (HCV) core protein in the transcriptional regulation of cellular and unrelated viral promoters. Furthermore, the core protein in cooperation with H-ras oncogene transforms primary rat embryo fibroblast cells to the tumorigenic phenotype. In the present study, the functional role of HCV core protein was investigated to determine its potential to inhibit me onset of apoptotic cell death. Expression of HCV core protein inhibited cisplatin mediated apoptosis In human cervical epithelial cells, and apoptosis induced by the overexpression of c-myc in Chinese hamster ovarian cells. Results from these studies suggest that the core protein may have a biological implication in the pathogenesis of HCV infection. (C) 1996 Academic Press Inc.