Evaluation of the Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating the Lymphocytic Cicatricial Alopecias
Evaluation of the Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating the Lymphocytic Cicatricial Alopecias
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DOI：
10.1159/000431174
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Abbas, Ossama
中科院分区：
文献类型：
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作者：
Sleiman, Rima;Kurban, Mazen;Abbas, Ossama
背景：淋巴细胞性瘢痕性脱发在临床上和组织病理学上的鉴别都很困难。目的：探讨浆细胞样树突状细胞（PDC）的存在和分布模式及其在鉴别红斑狼疮（LE）瘢痕性脱发与扁平苔藓（LPP）和额部纤维性脱发（FFA）中的诊断价值。方法：采用免疫组织化学方法检测17例LE相关性脱发、20例LPP和10例FFA患者的PDC存在/分布和活性。结果如下：LE相关性脱发表现出PDC含量增加（所有病例中>= 10% PDC，94%病例中>= 50% PDC）、PDC簇（100%病例）和更深的真皮和外分泌分布（100%病例），并累及真皮表皮连接（DEJ，94%病例），而大多数LPP和FFA均与皮肤表皮连接（DEJ，94%病例）有关。
Background: Differentiating lymphocytic scarring alopecias may be difficult clinically as well as histopathologically. Objective: To investigate plasmacytoid dendritic cell (PDC) presence and distribution patterns and their diagnostic value in differentiating scarring alopecias of lupus erythematosus (LE) from lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA). Methods: Seventeen LE-associated alopecia, 20 LPP and 10 FFA cases were immunohistochemically tested for PDC presence/distribution and activity. Results: LE-associated alopecia showed increased PDC content (>= 10% PDCs in all cases and >= 50% in 94% of cases), PDC clusters (100% of cases), and deeper dermal and perieccrine distribution (100% of cases) with involvement of the dermoepidermal junction (DEJ, 94% of cases), while the majority of LPP and FFA had