Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men - A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants
Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men - A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants
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DOI：
10.1093/oxfordjournals.aje.a009326
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发表时间：
1997-10-15
影响因子：
5
通讯作者：
Kuller, LH
中科院分区：
文献类型：
--
作者：
Zmuda, JM;Cauley, JA;Kuller, LH
本研究调查了 66 名 41-61 岁男性在 13 年来生活方式和行为与总睾酮变化的相关性，这些男性曾是宾夕法尼亚州匹兹堡中心多风险因素干预试验 (MRFIT) 的参与者。作者还确定了这些男性中总睾酮的变化是否与心血管疾病危险因素的变化有关。基线时平均总睾酮水平为 751（标准差，248）ng/dl，随访期间下降了 41（标准差，314）ng/dl。测量之间的相关性为 r = 0.44 (p < 0.001)。在多变量分析中，较高的 A 型冠状动脉倾向行为评分、较长的吸烟包年数和 MRFIT 特殊干预组与总睾酮的较大下降相关。年龄、体重、体重变化、闲暇活动水平和酒精摄入量与总睾酮的变化无关。在控制肥胖和其他生活方式协变量的多变量分析中，内源性睾酮的减少与甘油三酯的增加和高密度脂蛋白胆固醇的减少有关。睾酮的变化与总胆固醇和低密度脂蛋白胆固醇或血压的变化之间几乎没有关系。这项纵向研究证实，老年男性的总睾酮水平随着年龄的增长而逐渐下降，并提供了证据表明生活方式和社会心理因素与这种下降有关。男性内源性睾酮水平随着年龄的增长而下降，与甘油三酯和高密度脂蛋白胆固醇的潜在不利变化有关。
The present study examined lifestyle and behavioral correlates of the change in total testosterone over 13 years in 66 men aged 41-61 years who were former participants of the Multiple Risk Factor Intervention Trial (MRFIT) at the Pittsburgh, Pennsylvania, center. The authors also determined in these men if changes in total testosterone are related to changes in cardiovascular disease risk factors. The mean total testosterone level was 751 (standard deviation, 248) ng/dl at baseline and decreased by 41 (standard deviation, 314) ng/dl during follow-up. The correlation between measures was r = 0.44 (p < 0.001). In multivariate analysis, higher type A coronary-prone behavior score, greater pack-years of cigarette smoking, and the MRFIT special intervention group were associated with larger decreases in total testosterone. Age, body weight, weight change, leisure time activity level, and alcohol intake were not related to the change in total testosterone. The decrease in endogenous testosterone was associated with an increase in triglycerides and a decrease in high density lipoprotein cholesterol in multivariate analysis controlling for obesity and other lifestyle covariates. There was little relation between change in testosterone and change in total and low density lipoprotein cholesterol or blood pressure. This longitudinal study confirms a gradual decline in total testosterone levels with advancing age in older men and provides evidence that lifestyle and psychosocial factors are related to this decline. Decreases in endogenous testosterone levels with age in men are associated with potentially unfavorable changes in triglycerides and high density lipoprotein cholesterol.