Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease
Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease
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DOI：
10.1159/000452400
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发表时间：
2017-01-01
期刊：
影响因子：
3.2
通讯作者：
Nakamura, Masahiko
中科院分区：
文献类型：
--
作者：
Overby, Anders;Murayama, Somay Y.;Nakamura, Masahiko
背景：非幽门螺杆菌-幽门螺杆菌（Non-Helicobacter pylori-helicobacters，简称NHPH）是一类革兰氏阴性人畜共患细菌，可诱发人类胃炎、胃十二指肠溃疡和MALT淋巴瘤等胃病。据报道，其在普通人群中的患病率为0.1-6.2%，尽管此类报告的数量仍然较少。目的：本研究旨在估计日本人胃NHPH的患病率，并进一步将其与不同的胃疾病和幽门螺杆菌合并感染联系起来。方法：收集280例日本胃病患者的内镜活检标本。采用免疫组化和种特异性PCR检测胃幽门螺杆菌。结果：280例日本患者胃NHPH总患病率为6.1%，幽门螺杆菌总患病率为65.7%。分别感染幽门螺杆菌和NHPH时，NHPH和幽门螺杆菌的患病率均无显著差异。胃MALT淋巴瘤和十二指肠溃疡患者中NHPH感染最高，前者与幽门螺杆菌合并感染独立，后者与幽门螺杆菌合并感染依赖。结论：本研究报告了日本患者胃NHPH的总患病率为6.1%，并进一步强调了胃MALT淋巴瘤和十二指肠溃疡（当合并幽门螺杆菌感染时）是重要的相关疾病。(C) 2016 S. Karger AG，巴塞尔。
Background: Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number. Aims: This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori. Methods: Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters. Results: The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent. Conclusions: This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases. (C) 2016 S. Karger AG, Basel.