RESPONSES TO CORTICAL INJURY .1. METHODOLOGY AND LOCAL-EFFECTS OF CONTUSIONS IN THE RAT
RESPONSES TO CORTICAL INJURY .1. METHODOLOGY AND LOCAL-EFFECTS OF CONTUSIONS IN THE RAT
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DOI：
10.1016/0006-8993(81)90067-6
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
DAIL, WG
中科院分区：
文献类型：
--
作者：
FEENEY, DM;BOYESON, MG;DAIL, WG
为了对皮质挫伤的演变有一定的了解，在标准化损伤后的不同时间间隔进行了包括行为、形态学和组织化学在内的跨学科研究。描述了一种用于在大鼠中产生分级的和可再现的局灶性皮质挫伤的方法。当这些冲击损伤发生在后爪皮质区时，可以在对侧后肢中容易地观察到特定的创伤剂量依赖性行为缺陷。虽然大多数功能恢复发生在创伤后的前2周，但严重挫伤的功能障碍持续超过90天。从形态学上看，这些损伤从损伤后第一个小时内挫伤皮质下的白色物质中的肿胀发展到24小时内坏死空腔的发展。空化似乎在随后的2周内扩大，到15天时，成纤维细胞样成分和巨噬细胞排列在一起。在坏死区域的边缘可见强酸性磷酸酶活性。这种溶酶体酶可能参与皮质挫伤后的自溶和局灶性空化的发展。
To develop some understanding of the evolution of cortical contusions, interdisciplinary studies including behavior, morphology and histochemistry were conducted at varying intervals after standardized injuries. A method for producing graded and reproducible focal cortical contusions in the rat is described. When these impact injuries are made in the hindpaw cortical area, specific trauma dose dependent behavioral deficits can be readily observed in the contralateral hindlimb. While most functional recovery occurs in the first 2 wk after trauma, with severe contusions, deficits persist beyond 90 days. Morphologically these injuries progress from hemorrhages in white matter directly under contused cortex during the first hours after injury to the development of a necrotic cavity by 24 h. The cavitation appears to expand over the subsequent 2 wk and by 15 days is lined with fibroblast-like elements and macrophages. Intense acid phosphatase activity is seen on the borders of the area of necrosis. This lysosomal enzyme may participate in autolysis and development of focal cavitation following cortical contusion.