Increased small low-density lipoprotein particle number - A prominent feature of the metabolic syndrome in the Framingham Heart Study
Increased small low-density lipoprotein particle number - A prominent feature of the metabolic syndrome in the Framingham Heart Study
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DOI：
10.1161/circulationaha.105.567107
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发表时间：
2006-01-03
期刊：
影响因子：
37.8
通讯作者：
Robins, SJ
中科院分区：
文献类型：
--
作者：
Kathiresan, S;Otvos, JD;Robins, SJ
背景-在代谢综合征（MetSyn）患者中，LDL胆固醇（LDL-C）水平通常不升高。然而，LDL的致动脉粥样硬化潜力可能取决于LDL颗粒的数量和大小，以及LDL中胆固醇的含量。（通过核磁共振光谱法测定）与2993例心脏研究参与者中MetSyn及其组分的存在相关（平均年龄，51岁; 53%的女性）没有心血管疾病（CVD）和小LDL颗粒数量与MetSyn人群CVD发病率的关系。MetSyn（由国家胆固醇教育成人治疗小组III定义的5个特征中>= 3个）存在于27%的男性和17%的女性中。在两种性别中，小LDL颗粒数量从0增加到5个MetSyn性状，这种模式部分归因于小LDL颗粒数量与血清甘油三酯（r=0.61，P < 0.0001）和HDL-C（r=-0.55，P < 0.0001）之间的强相关性。与没有MetSyn的参与者相比，MetSyn的参与者有更高的CVD事件发生率。然而，与MetSyn的参与者中，CVD率是相似的组与升高与较低数量的小LDL颗粒（定义的性别特异性中位数）。结论-小LDL颗粒数量升高的MetSyn，增加与MetSyn组件的数量，最显着的是与甘油三酯和HDL-C。虽然小LDL颗粒数量增加识别MetSyn具有高灵敏度，但在MetSyn人群中，更高的小LDL颗粒数量与更高的CVD事件发生率无关。
Background-Levels of LDL cholesterol (LDL-C) are frequently not elevated in individuals with the metabolic syndrome (MetSyn). However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL.Methods and Results-We examined the sex-specific cross-sectional relations of small LDL particle number ( determined by nuclear magnetic resonance spectroscopy) to the presence of MetSyn and its components in 2993 Framingham Heart Study participants ( mean age, 51 years; 53% women) without cardiovascular disease (CVD) and the relations of small LDL particle number to CVD incidence in people with MetSyn. The MetSyn (>= 3 of 5 traits as defined by the National Cholesterol Education Adult Treatment Panel III) was present in 27% of men and 17% of women. In both sexes, small LDL particle number increased from 0 to 5 MetSyn traits, a pattern partly accounted for by strong correlations between small LDL particle number and serum triglycerides (r=0.61, P < 0.0001) and HDL-C (r=-0.55, P < 0.0001). Compared with participants without the MetSyn, those with the MetSyn had a higher CVD event rate. However, among participants with the MetSyn, CVD rates were similar for groups with an elevated versus a lower number of small LDL particles ( defined by the sex-specific median).Conclusions-Small LDL particle number is elevated in the MetSyn, increases with the number of MetSyn components, and most prominently is correlated with triglycerides and HDL-C. Whereas increased small LDL particle number identified the MetSyn with high sensitivity, a higher small LDL particle number was not associated with greater CVD event rates in people with the MetSyn.