RETARDATION OF ETHANOL ABSORPTION BY FOOD IN THE STOMACH
RETARDATION OF ETHANOL ABSORPTION BY FOOD IN THE STOMACH
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DOI：
10.15288/jsa.1980.41.861
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
WESTCOTT, J
中科院分区：
文献类型：
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作者：
SHULTZ, J;WEINER, H;WESTCOTT, J
口服乙醇（2.3 g/kg体重）喂养的大鼠血液酒精浓度（BAC）低于禁食的大鼠，饮用6%乙醇溶液并食用固体食物的大鼠血液酒精浓度（BAC）也低于饮用等量乙醇的液体食物的大鼠；研究了造成这些差异的原因。从喂食大鼠的胃中释放出的给药乙醇不到40%，与没有食物颗粒的禁食大鼠的胃相比，乙醇扩散的速度要慢。未释放的乙醇可以被回收，说明胃及其内容物都没有代谢乙醇。喂食大鼠的低BAC显然是由于胃中存在的固体食物颗粒对乙醇的吸收。
Fed rats given ethanol orally (2.3 g/kg body wt) had lower blood alcohol concentrations (BAC) than fasted rats and BAC were also lower in rats drinking a 6% ethanol solution and eating solid food than in rats drinking a similar amount of ethanol in a liquid diet; the reasons for these differences were investigated. Less than 40% of the administered ethanol was released from stomachs isolated from fed rats and the rates of ethanol diffusion were slower compared with stomachs from fasted rats, which were devoid of food particles. The unreleased ethanol could be recovered, indicating that neither the stomach nor its contents metabolized ethanol. Low BAC in fed rats evidently are a result of the absorption of ethanol by solid food particles present in the stomach.