Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.
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DOI:
10.1016/j.ceb.2009.01.004
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发表时间:
2009-02
影响因子:
7.5
通讯作者:
Funabiki H
中科院分区:
文献类型:
--
作者:
Kelly AE;Funabiki H
The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connection between the spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments can be recognized and processed by the Aurora B pathway.
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