Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.
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DOI:
10.1016/j.ceb.2009.01.004
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发表时间:
2009-02
影响因子:
7.5
通讯作者:
Funabiki H
Funabiki H
中科院分区:
生物学2区
文献类型:
--
作者:
Kelly AE;Funabiki H

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在有丝分裂和减数分裂过程中,染色体的定向运动依赖于微管介导的纺锤体极与染色体上组装的动粒之间的连接。微管和动粒之间动态相互作用的分子基础才刚刚开始被揭开。在这里,集中在有丝分裂着丝粒激酶极光B,我们审查我们目前的理解,纠正错误的微管附着在着丝粒的信号通路。我们评估了几个潜在的模型,可以解释如何定向不良的附件可以识别和处理的极光B途径。
The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connection between the spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments can be recognized and processed by the Aurora B pathway.
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