Contemporary Methods Allowing for Safe and Convenient Use of Amniotic Membrane as a Biologic Wound Dressing for Burns
Contemporary Methods Allowing for Safe and Convenient Use of Amniotic Membrane as a Biologic Wound Dressing for Burns
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DOI：
10.1097/sap.0000000000000979
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发表时间：
2017-02-01
影响因子：
1.5
通讯作者：
Branski, Ludwik K.
中科院分区：
文献类型：
--
作者：
Herndon, David N.;Branski, Ludwik K.
部分皮层烧伤涉及皮肤上层的损伤，这使得神经末梢暴露，因此代表了几种热损伤中最痛苦的。历史上，部分皮层烧伤的保守治疗方法是清除水泡，每天洗盆和冲洗，以及使用新绷带和局部药物。人羊膜作为生物伤口敷料已经使用了几个世纪。在过去的20年里，有越来越多的文献涉及羊膜组织在慢性伤口和烧伤中的应用。本文就羊膜在烧伤治疗中的应用，包括处理方法和早期临床应用作一综述。我们相信羊膜在未来改善烧伤创面护理方面具有很大的潜力。标准化的加工方法和最终灭菌确保了安全性，并使该材料可供世界各地的医疗保健提供者在临床试验和患者护理中使用。
Partial-thickness burns involve damage to the upper layer of skin, which leaves nerve endings exposed, and therefore represent the most painful of several categories of thermal injuries. Historically, partial-thickness burns were treated conservatively by debriding the blisters, by daily tubbing and washing, and the application of new bandages with topical medications. Human amniotic membrane has been used for centuries as a biological wound dressing. In the past 20 years, there has been an increasing body of literature addressing the use of amniotic tissue in chronic wounds and burns. In this review, we present an overview of the use of amniotic membrane in the treatment of burns including processing methods and early clinical use. We believe that amniotic membranes have great potential in improving burn wound care in the future. Standardized processing methods and terminal sterilization ensure safety and allow the material to be available for use by health care providers around the world in clinical trials and for patient care.