Isoflurane and Sevoflurane Augment Norepinephrine Responses to Surgical Noxious Stimulation in Humans
Isoflurane and Sevoflurane Augment Norepinephrine Responses to Surgical Noxious Stimulation in Humans
复制标题
异氟烷和七氟烷增强去甲肾上腺素对人类手术有害刺激的反应
DOI：
10.1097/00000542-199812000-00018
复制
发表时间：
1998
期刊：
影响因子：
8.8
通讯作者：
T. Arai
中科院分区：
文献类型：
--
作者：
H. Segawa;K. Mori;M. Murakawa;K. Kasai;G. Shirakami;T. Adachi;T. Arai
Background Suppression of hypertensive response to noxious stimulation by volatile anesthetics may be a result of suppression of the stimulation‐induced norepinephrine response or that of the cardiovascular response to catecholamines, or both. The suppression of the cardiovascular response is established, but that of norepinephrine response has not been confirmed. The authors hypothesized that the suppression of cardiovascular response but not that of norepinephrine response plays a major role in suppressing the noxious stimulation‐induced hypertensive response by volatile anesthetics. Methods Forty healthy donors for living‐related liver transplantation were allocated to four groups: receiving 1.2% (end‐tidal) isoflurane in oxygen and nitrogen, 2.0% isoflurane, 1.7% sevoflurane, or 2.8% sevoflurane. The intraoperative plasma norepinephrine and epinephrine concentrations, arterial blood pressure and pulse rate were measured for the first 15 min of surgery and were compared with the preoperative values. Results Norepinephrine and epinephrine concentrations both increased intraoperatively in all four groups. The values of maximum increase the area under the concentration‐versus‐time curve of norepinephrine were greater in the high dose groups of both anesthetics. The intraoperative blood pressure did not differ by different doses of anesthetics, and the degree of increase of blood pressure was not proportional to the plasma catecholamine concentrations. Conclusion The effects of isoflurane and sevoflurane on the surgical noxious stimulation‐induced norepinephrine response were inversely proportional to the dose. The suppression of noxious stimulation‐induced blood pressure response by anesthetics that were studied may be the result of suppression of the responses of vascular smooth muscle and myocardium to catecholamines.
异氟醚对犬脑动脉离体平滑肌细胞 K 和 Ca2 电导的影响。
影响因子：
5.7
作者：
Buljubasic,N;Flynn,NM;Marijic,J;Rusch,NJ;Kampine,JP;Bosnjak,ZJ
通讯作者：
Bosnjak,ZJ
影响因子：
8.8
作者：
BULJUBASIC, N;RUSCH, NJ;BOSNJAK, ZJ
通讯作者：
BOSNJAK, ZJ