High-Resolution Extremity Cone-Beam CT with a CMOS Detector: Evaluation of a Clinical Prototype in Quantitative Assessment of Bone Microarchitecture.
High-Resolution Extremity Cone-Beam CT with a CMOS Detector: Evaluation of a Clinical Prototype in Quantitative Assessment of Bone Microarchitecture.
复制标题
配备 CMOS 探测器的高分辨率四肢锥束 CT：骨微结构定量评估中临床原型的评估。
DOI：
10.1117/12.2293810
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Zbijewski,W
中科院分区：
文献类型：
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作者：
Cao,Q;Brehler,M;Sisniega,A;Tilley2nd,S;ShirazBhruwani,MM;Stayman,JW;Yorkston,J;Siewerdsen,JH;Zbijewski,W
目的：开发了一种基于CMOS探测器的原型高分辨率四肢锥束CT（CBCT）系统，以支持骨微结构的定量体内评估。我们比较了CMOS CBCT的性能，非晶硅（a-Si：H）FPD四肢CBCT在trabecular bone.Methods成像：原型CMOS CBCT包括一个DALSA Xineos 3030探测器（99 μm像素）与400 μ m厚的碘化铯闪烁体和一个紧凑的0.3 FS旋转阳极X射线源。我们将CMOS CBCT的性能与构建在类似机架上的a-Si：H FPD扫描仪进行比较，但使用具有0.137 mm像素和0.5 FS固定阳极X射线源的Varian PaxScan 2530探测器。实验研究包括测量探测器的调制传递函数（MTF）和3D图像重建。临床场景中的图像质量在尸体踝关节的扫描中进行评价。使用CMOS CBCT和a-Si：H FPD CBCT在人尺骨中获得骨小梁微结构（BV/TV，骨体积/总体积，TbSp，骨小梁间距，和TbTh，骨小梁厚度）的测量，并与金标准μCT进行比较。结果：与a-Si：H FPD相比，CMOS探测器在f20值（MTF降低至0.20的频率）方面实现了约40%的增加。在重构域，127 μm钨丝的半高宽也提高了约40%。尸体踝关节的重建显示了CMOS探测器对小梁结构的增强调制和与a-Si：H FPD系统相似的软组织可见性。CMOS CBCT改善了骨微结构指标与金标准μCT的相关性：BV/TV从0.93提高到0.98，TbTh从0.49提高到0.74，TbSp从0.9提高到0.96。结论：与传统a-Si：H FPD相比，在肢体CBCT中采用CMOS探测器提高了空间分辨率，增强了骨微结构指标的性能。该结果支持CMOS CBCT在骨健康定量成像中的临床应用的发展。
Purpose: A prototype high-resolution extremity cone-beam CT (CBCT) system based on a CMOS detector was developed to support quantitative in vivo assessment of bone microarchitecture. We compare the performance of CMOS CBCT to an amorphous silicon (a-Si:H) FPD extremity CBCT in imaging of trabecular bone.Methods: The prototype CMOS-based CBCT involves a DALSA Xineos3030 detector (99 μm pixels) with 400 μm-thick CsI scintillator and a compact 0.3 FS rotating anode x-ray source. We compare the performance of CMOS CBCT to an a- Si:H FPD scanner built on a similar gantry, but using a Varian PaxScan2530 detector with 0.137 mm pixels and a 0.5 FS stationary anode x-ray source. Experimental studies include measurements of Modulation Transfer Function (MTF) for the detectors and in 3D image reconstructions. Image quality in clinical scenarios is evaluated in scans of a cadaver ankle. Metrics of trabecular microarchitecture (BV/TV, Bone Volume/Total Volume, TbSp, Trabecular Spacing, and TbTh, trabecular thickness) are obtained in a human ulna using CMOS CBCT and a-Si:H FPD CBCT and compared to gold standard μCT.Results: The CMOS detector achieves ~40% increase in the f20 value (frequency at which MTF reduces to 0.20) compared to the a-Si:H FPD. In the reconstruction domain, the FWHM of a 127 μm tungsten wire is also improved by ~40%. Reconstructions of a cadaveric ankle reveal enhanced modulation of trabecular structures with the CMOS detector and soft-tissue visibility that is similar to that of the a-Si:H FPD system. Correlations of the metrics of bone microarchitecture with gold-standard μCT are improved with CMOS CBCT: from 0.93 to 0.98 for BV/TV, from 0.49 to 0.74 for TbTh, and from 0.9 to 0.96 for TbSp.Conclusion: Adoption of a CMOS detector in extremity CBCT improved spatial resolution and enhanced performance in metrics of bone microarchitecture compared to a conventional a-Si:H FPD. The results support development of clinical applications of CMOS CBCT in quantitative imaging of bone health.