Adipokines: a link between obesity and dementia?
Adipokines: a link between obesity and dementia?
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DOI：
10.1016/s1474-4422(14)70085-7
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发表时间：
2014-09
期刊：
影响因子：
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通讯作者：
Gustafson DR
中科院分区：
文献类型：
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作者：
Kiliaan AJ;Arnoldussen IA;Gustafson DR
超重或肥胖，如用体重指数（BMI）或中心性肥胖（腰围）测量的，以及BMI在生命过程中的演变轨迹，与脑萎缩、白色物质变化、血脑屏障完整性和全因迟发性痴呆和阿尔茨海默病（AD）的风险相关。这一观察结果让我们质疑BMI与大脑健康和痴呆风险的关系。如果高BMI和中心性肥胖代表脂肪组织的增加，那么由脂肪组织激素和脂肪因子介导的脂肪组织的内分泌方面可能是理解痴呆和AD相关性的线索。已经鉴定了数百种脂肪因子，这造成了一种复杂性，难以简化。尽管如此，脂肪因子正在研究与临床痴呆症的结果，以及基于成像的脑体积，结构和功能的临床前和临床痴呆症的人类模型的措施。
Being overweight or obese, as measured with body mass index (BMI) or central adiposity (waist circumference), and evolving trajectory of BMI over the life course, have been associated with brain atrophy, white matter changes, blood brain barrier integrity and risk of all-cause late-onset dementia and Alzheimer’s Disease (AD). This observation leads us to question what it is about BMI that is associated with health of the brain and dementia risk. If high BMI and central adiposity represent an increase in adipose tissue, then the endocrine aspect of adipose tissue, mediated by adipose tissue hormones and adipokines, may be a clue to understanding the association with dementia and AD. Hundreds of adipokines have been identified, creating a complexity that is challenging to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, as well as imaging-based measures of brain volume, structure and function in preclinical and human models of clinical dementia.