Normalisation of Angiogenic Imbalance after Intra-Uterine Transfusion for Mirror Syndrome Caused by Parvovirus B19
Normalisation of Angiogenic Imbalance after Intra-Uterine Transfusion for Mirror Syndrome Caused by Parvovirus B19
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DOI：
10.1159/000348778
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
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作者：
Goa, Satoko;Mimura, Kazuya;Kimura, Tadashi
我们报告一例由细小病毒B19引起的镜像综合征，在宫内输血后消退。镜像综合征是一种罕见的疾病，其特征是胎儿水肿，全身性母体水肿和胎盘肥大三联征。虽然这种综合征的发病机制尚不清楚，但它可能与先兆子痫有共同的病理生理起源。我们的患者显示循环中可溶性fms样酪氨酸激酶1（sFlt-1）水平升高，胎盘生长因子（PlGF）水平降低，这也在先兆子痫中有报道。sFlt-1/PIGF比率在子宫内输血后立即降低，随后母体和胎儿症状均消退。这表明sFlt-1/PIGF比值可能有助于预测镜像综合征的治疗后病程。版权所有（C）2013 S. Karger AG，巴塞尔
We report a case of mirror syndrome caused by parvovirus B19, which resolved after intra-uterine transfusion. Mirror syndrome is a rare condition characterised by a triad of foetal hydrops, generalized maternal oedema and placentomegaly. Although the mechanism underlying the onset of this syndrome is unknown, it probably shares a common pathophysiologic origin with pre-eclampsia. Our patient showed increased circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and decreased levels of placental growth factor (PIGF), which have also been reported in pre-eclampsia. The sFlt-1/PIGF ratio decreased immediately after intra-uterine transfusion, followed by resolution of both maternal and foetal symptoms. This suggests that the sFlt-1/PIGF ratio may help to predict the post-treatment course of mirror syndrome. Copyright (C) 2013 S. Karger AG, Basel