Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis
Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis
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DOI：
10.1007/s11325-012-0677-3
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发表时间：
2013-03-01
影响因子：
2.5
通讯作者：
El-Solh, Ali A.
中科院分区：
文献类型：
--
作者：
Anandam, Anil;Akinnusi, Morohunfolu;El-Solh, Ali A.
临床和流行病学调查表明，肥胖和阻塞性睡眠呼吸暂停（OSA）之间存在密切联系。本研究的目的是评估目前可用的关于饮食减肥治疗肥胖患者阻塞性睡眠呼吸暂停综合征有效性的文献。通过计算机检索PubMed、EMBASE、CINAHL、Web of Science和The科克伦中央对照试验登记册（截至2011年9月）以及所有获得的文章的参考列表来识别相关研究。获得了研究设计、患者特征、饮食前后OSA和体重指数（BMI）的体重减轻指标以及研究质量的相关信息。由两名独立分析员提取数据。使用随机效应模型的加权平均值报告95%置信区间。选择了代表577例患者的9篇文章。饮食减肥计划导致合并平均BMI降低4.8 kg/m2（95%置信区间[CI] 3.8-5.9）。饮食干预前后的随机效应合并呼吸暂停低通气（AHI）指数分别为52.5（范围10.0-91.0）和28.3事件/h（范围5.4-64.5）（p < 0.001）。与对照组相比，AHI的加权平均差异降低了-14.3次事件/h（95%CI-23.5至-5.1; p = 0.002），这有利于饮食减肥计划。饮食减肥计划可有效降低OSA的严重程度，但不足以缓解所有呼吸事件。减肥计划应被视为辅助治疗，而不是治愈性治疗。
Clinical and epidemiologic investigations suggest a strong association between obesity and obstructive sleep apnea (OSA). The purpose of this study is to evaluate the currently available literature reporting on the effectiveness of dietary weight loss in treating OSA among obese patients.Relevant studies were identified by computerized searches of PubMed, EMBASE, CINAHL, Web of Science, and The Cochrane Central Register of Controlled Trials through September 2011 as well as the reference lists of all obtained articles. Information on study design, patient characteristics, pre- and post-dietary weight loss measures of OSA and body mass index (BMI), and study quality was obtained. Data were extracted by two independent analysts. Weighted averages using a random-effects model are reported with 95 % confidence intervals.Nine articles representing 577 patients were selected. Dietary weight loss program resulted in a pooled mean BMI reduction of 4.8 kg/m(2) (95 % confidence interval [CI] 3.8-5.9). The random-effects pooled apnea hypopnea (AHI) indices at pre- and post-dietary intervention were 52.5 (range 10.0-91.0) and 28.3 events/h (range 5.4-64.5), respectively (p < 0.001). Compared to control, the weighted mean difference of AHI was decreased by -14.3 events/h (95 % CI -23.5 to -5.1; p = 0.002) in favor of the dietary weight loss programs.Dietary weight loss programs are effective in reducing the severity of OSA but not adequate in relieving all respiratory events. Weight reduction programs should be considered as adjunct rather than curative therapy.