Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation.
Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation.
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DOI：
10.1002/hep.29106
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Rosen HR
中科院分区：
文献类型：
--
作者：
Golden-Mason L;Rosen HR
聚糖结合蛋白，包括半乳糖凝集素，参与免疫和炎症的所有阶段，从起始到消退。半乳糖凝集素-9（Galectin-9，Gal-9）在肝脏中高度表达，并在先天性和适应性免疫中具有多种生物学功能，这些功能有助于维持肝脏稳态。在病毒性肝炎的情况下，Gal-9的表达增加驱动调节性T细胞的扩增和效应T细胞的收缩，从而有利于病毒持续存在。Gal-9的二分性质在肝细胞癌中是明显的，其中肝细胞中的表达缺失促进肿瘤生长和转移，而枯否细胞和内皮细胞的过表达抑制抗肿瘤免疫应答。在非酒精性脂肪肝疾病中，Gal-9间接参与保护性自然杀伤T细胞群的扩增。在缺血性肝损伤中，肝细胞衍生的Gal-9既是诊断性的又是细胞保护性的。在药物诱导的急性肝衰竭中，血浆水平与结果相关。在这里，我们提供了一个合成的最新和新兴的发现Gal-9在肝脏炎症的调节。正在进行的研究有必要更好地阐明肝脏免疫介导的疾病的病理生理学，并使用聚糖结合蛋白开发新的治疗干预措施。
Glycan-binding proteins, which include galectins, are involved at all stages of immunity and inflammation, from initiation through resolution. Galectin-9 (Gal-9) is highly expressed in the liver and has a wide variety of biological functions in innate and adaptive immunity that are instrumental in the maintenance of hepatic homeostasis. In the setting of viral hepatitis, increased expression of Gal-9 drives the expansion of regulatory T cells and contraction of effector T cells, thereby favoring viral persistence. The dichotomous nature of Gal-9 is evident in hepatocellular carcinoma, where loss of expression in hepatocytes promotes tumor growth and metastasis, whereas overexpression by Kupffer cells and endothelial cells inhibits the antitumor immune response. In nonalcoholic fatty liver disease, Gal-9 is involved indirectly in the expansion of protective natural killer T-cell populations. In ischemic liver injury, hepatocyte-derived Gal-9 is both diagnostic and cytoprotective. In drug-induced acute liver failure, plasma levels correlate with outcome. Here, we offer a synthesis of recent and emerging findings on Gal-9 in the regulation of hepatic inflammation. Ongoing studies are warranted to better elucidate the pathophysiology of hepatic immune-mediated diseases and to develop new therapeutic interventions using glycan-binding proteins.
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影响因子：
25.7
作者：
Liu, Yuanxing;Ji, Haofeng;Zhang, Yu;Shen, Xiuda;Gao, Feng;He, Xiangyi;Li, Gabriella A.;Busuttil, Ronald W.;Kuchroo, Vijay K.;Kupiec-Weglinski, Jerzy W.
通讯作者：
Kupiec-Weglinski, Jerzy W.
DOI：
10.1016/j.bbadis.2013.12.003
发表时间：
2014-02-01
影响因子：
6.2
作者：
Heusschen, Roy;Schulkens, Iris A.;Thijssen, Victor L.
通讯作者：
Thijssen, Victor L.
影响因子：
3.7
作者：
Barjon C;Niki T;Vérillaud B;Opolon P;Bedossa P;Hirashima M;Blanchin S;Wassef M;Rosen HR;Jimenez AS;Wei M;Busson P
通讯作者：
Busson P
影响因子：
3.7
作者：
Lv K;Zhang Y;Zhang M;Zhong M;Suo Q
通讯作者：
Suo Q
Tim-3/galectin-9信号通路介导T细胞功能障碍并预测乙型肝炎病毒相关性肝细胞癌患者的不良预后
影响因子：
13.5
作者：
Li, Hang;Wu, Ke;Zou, Weiping
通讯作者：
Zou, Weiping