Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
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DOI：
10.1038/s41593-020-0674-y
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发表时间：
2020-07-27
影响因子：
25
通讯作者：
Grinevich, Valery
中科院分区：
文献类型：
--
作者：
Tang, Yan;Benusiglio, Diego;Grinevich, Valery
催产素（OT）是社会生活的一个伟大的促进者，但是，尽管它对社会相关的大脑区域的影响已经被广泛研究，在实际的社会交往中OT神经元的活动仍然没有被探索。大多数OT神经元是大细胞神经元，它们同时投射到参与社会行为的垂体和前脑区域。在本研究中，我们发现，一个更小的人口OT神经元，小细胞神经元，不投影到垂体，但突触到大细胞神经元，优先激活体感刺激。这种激活被传递到大细胞神经元的更大的人口，从而显示出协调的增加，其活动在社会之间的互动处女雌性大鼠。选择性地激活这些小细胞神经元会促进社会动机，而抑制它们会减少社会互动。因此，小细胞催产素神经元通过协调大细胞催产素神经元的反应来接收特定的输入以控制社会行为。Charlet，Grinevich等人表明，雌性大鼠之间的社会接触激活了小细胞催产素神经元;这些神经元通过协调大细胞催产素神经元的反应来控制社会行为。
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons.Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons.