Relationship between penile erection and the ratio of estradiol to testosterone: A retrospective study
Relationship between penile erection and the ratio of estradiol to testosterone: A retrospective study
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阴茎勃起与雌二醇与睾酮比率之间的关系：一项回顾性研究
DOI：
10.1111/and.13701
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发表时间：
2020-06-15
期刊：
影响因子：
2.4
通讯作者：
Zhao, Sheng-Tian
中科院分区：
文献类型：
--
作者：
Pan, Dong;Xu, Zhi-He;Zhao, Sheng-Tian
先前的研究发现，雌二醇与睾丸激素的比率（E2/T比）对性功能具有负面影响，但是E2/T比与阴茎勃起之间的关系尚未澄清。我们对183例勃起功能障碍患者和52名健康男性进行了回顾性研究，以研究阴茎碱基勃起与尖端勃起之间的关系。所有参与者都进行了夜间阴茎肿瘤测试和病史检查，并测量了相关的生化和内分泌指标。计算了雌二醇与睾丸激素的比率。通过单变量分析，多变量分析和分层分析，确定了阴茎尖端和阴茎碱基的E2/T比与勃起时间之间的关系。调整了混合因子后，结果表明，与阴茎尖端相比，E2/T比对阴茎的底部具有更明显的负面影响（危险比：-4.34 95％CI：-6.52，-2.16p = .0001）。此外，当有效的勃起时间> = 10分钟时，E2/T对阴茎根勃起的负面影响更为明显（HR比：-4.46 95％CI：-6.50，-2.43p <.0001）。总而言之，我们的研究表明E2/T比与阴茎勃起之间存在负相关关系，尤其是在阴茎的根源上。
Previous studies have found that the ratio of estradiol to testosterone (E2/T ratio) has a negative effect on sexual function, but the relationship between the E2/T ratio and erection of the penis is not clarified. We conducted a retrospective study of 183 patients with erectile dysfunction and 52 healthy men to investigate the relationship between penis base erection and tip erection. All participants underwent nocturnal penile tumescence tests and medical history checks and had relevant biochemical and endocrine indicators measured. The ratio of estradiol to testosterone was calculated. The relationship between E2/T ratio and erectile time of penile tip and penile base was determined by univariate analysis, multivariate analysis and stratification analysis. After adjusting for mixed factors, the results showed that the E2/T ratio had a more significant negative effect on the base of the penis compared with the tip of the penis (Hazard ratio: -4.34 95% CI: -6.52, -2.16p = .0001). Moreover, when the effective erection time was >= 10 min, the negative effect of E2/T on penile root erection was more obvious (HR ratio: -4.46 95% CI: -6.50, -2.43p < .0001). In summary, our study demonstrated a negative relationship between E2/T ratio and penile erection, particularly at the root of the penis.