NEURONAL-ACTIVITY IN MONKEY VENTRAL STRIATUM RELATED TO THE EXPECTATION OF REWARD
NEURONAL-ACTIVITY IN MONKEY VENTRAL STRIATUM RELATED TO THE EXPECTATION OF REWARD
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DOI：
10.1523/jneurosci.12-12-04595.1992
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发表时间：
1992-12-01
影响因子：
5.3
通讯作者：
LJUNGBERG, T
中科院分区：
文献类型：
--
作者：
SCHULTZ, W;APICELLA, P;LJUNGBERG, T
从皮质和皮质下边缘结构到基底神经节的投射主要指向腹侧纹状体。本研究探讨了具有行为意义的外部事件的预期如何反映在腹侧纹状体神经元的活动中。在猕猴执行延迟的go-no-go任务中，共研究了420个神经元。几秒钟后，当触发灯亮起时，不同颜色的灯分别指示动物做手臂伸展运动或不动。在这两种情况下，液体奖励的任务表现得到加强。共有60腹侧纹状体神经元表现出持续增加的活动之前，个别任务事件的发生。在其中43个神经元中，激活特异性地先于奖励的传递，独立于运动或非运动反应。在一系列额外的测试中，这些激活被锁定在随后的奖励上，当奖励被省略时，在几次试验中消失，并且在时间上与嘴巴运动无关。奖励液体的食欲值的变化改变了激活的幅度，这表明可能与预期事件的享乐属性有关。当奖励以一种可预测的方式在任何行为任务之外传递时，也会发生激活。这些数据表明，腹侧纹状体的神经元在个体环境事件的预期状态下被激活，这些事件是受试者通过其过去的经验可预测的。与奖励期望相关的激活的普遍性表明腹侧纹状体神经元可以访问奖励的中央表征，从而参与目标导向行为的动机控制的信息处理。
Projections from cortical and subcortical limbic structures to the basal ganglia are predominantly directed to the ventral striatum. The present study investigated how the expectation of external events with behavioral significance is reflected in the activity of ventral striatal neurons. A total of 420 neurons were studied in macaque monkeys performing in a delayed go-no-go task. Lights of different colors instructed the animal to do an arm-reaching movement or refrain from moving, respectively, when a trigger light was illuminated a few seconds later. Task performance was reinforced by liquid reward in both situations. A total of 60 ventral striatal neurons showed sustained increases of activity before the occurrence of individual task events. In 43 of these neurons, activations specifically preceded the delivery of reward, independent of the movement or no-movement reaction. In a series of additional tests, these activations were time locked to the subsequent reward, disappeared within a few trials when reward was omitted, and were temporally unrelated to mouth movements. Changes in the appetitive value of the reward liquid modified the magnitude of activations, suggesting a possible relationship to the hedonic properties of the expected event. Activations also occurred when reward was delivered in a predictable manner outside of any behavioral task. These data suggest that neurons in the ventral striatum are activated during states of expectation of individual environmental events that are predictable to the subject through its past experience. The prevalence of activations related to the expectation of reward suggests that ventral striatal neurons have access to central representations of reward and thereby participate in the processing of information underlying the motivational control of goal-directed behavior.