Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy
Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy
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DOI：
10.1111/j.1528-1167.2008.01596.x
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发表时间：
2008-08-01
期刊：
影响因子：
5.6
通讯作者：
Lueders, Hans O.
中科院分区：
文献类型：
--
作者：
Diehl, Beate;Busch, Robyn M.;Lueders, Hans O.
目的：为探讨颞叶癫痫（TLE）患者钩束（UF）的结构完整性和连通性及其与记忆能力的关系，采用弥散张量成像（DTI）技术对28例TLE患者（左侧18例，右侧10例）和10例正常对照者进行了DTI和UF重建。计算TLE组左右UF各向异性分数（FA）和表观扩散系数（ADC）值之间的差异以及DTI测量值与记忆评分之间的相关性。在左侧TLE中，左侧UF的FA值低于对照组，ADC值高于对照组，而右侧UF的ADC值高于对照组（均p <0.05）。在右侧TLE中，与对照组相比，左侧和右侧UF中的ADC较高，左侧UF中的FA降低（所有p <0.05）。左侧颞叶癫痫患者左侧UF的ADC值与听觉即刻（p <0.05）和延迟记忆（p <0.01）呈负相关。视觉延迟记忆与右侧UF ROI中FA减少和径向扩散率增加呈正相关（p <0.05）。右侧TLE无明显相关性。因此，DTI值与记忆分数在预期的方向与左TLE.Conclusions患者：在UF同侧癫痫区的异常扩散措施表明，完整的UF与左TLE患者的记忆性能。需要更大的样本量来进一步评估结构-功能相关性。
Aims: To use Diffusion Tensor Imaging (DTI) to explore structural integrity and connectivity of the uncinate fasciculus (UF) in patients with temporal lobe epilepsy (TLE) and its relationship to memory performance.Methods: DTI and UF reconstruction were performed in 28 patients with TLE (18 left, 10 right) and 10 normal controls. Differences between left and right UF fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values and correlations between DTI measures and memory scores in the TLE groups were computed.Results: In controls, FA was higher in the left than right UF (p < 0.01). In left TLE, FA values were lower and ADC values higher than controls in the left UF and ADC values were higher in the right UF (all p < 0.05). In right TLE, ADCs were higher in the left and right UF compared to controls, and FA was reduced in the left UF (all p < 0.05). In left TLE, ADCs in the left UF were negatively correlated with Auditory Immediate (p < 0.05) and Delayed Memory (p < 0.01). Visual Delayed Memory was positively correlated with reduced FA in the ROI of the right UF and increased radial diffusivities (p < 0.05). No significant correlations were found in right TLE. Thus, DTI values correlated with memory scores in the expected direction in patients with left TLE.Conclusions: Abnormal diffusion measures in the UF ipsilateral to the epileptogenic zone suggest that integrity of the UF is related to memory performance in patients with left TLE. Larger sample sizes are needed to evaluate structure-function correlations further.