Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiatio

Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiation-induced neurological complications of nasopharyngeal carcinoma Radiatio
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发表时间：
1999
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影响因子：
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通讯作者：
L. Tan;Y. Sitoh;H. Tjia
L. Tan;Y. Sitoh;H. Tjia
中科院分区：
其他
文献类型：
--
作者：
L. Tan;Y. Sitoh;H. Tjia

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目的：探讨鼻咽癌放射性神经系统并发症。材料和方法：回顾性分析1994年至1999年五年间到陈笃生医院神经内科和神经外科就诊的鼻咽癌放射性神经系统并发症患者。结果：9例患者出现10例神经系统并发症。4例患者有脑神经麻痹，其中2例有视神经萎缩，1例有孤立的第三神经病变，另1例有合并的第三，第四和第五脑神经麻痹。3例患者分别有颞叶坏死和颈脊髓病。其中两名颞叶坏死的患者出现癫痫发作，而第三名患者出现抗利尿激素分泌不当综合征。2例视神经萎缩和2例颈脊髓病患者接受抗凝治疗。视神经萎缩的患者得到改善，而脊髓型颈椎病的患者稳定。结论：鼻咽癌放射治疗可引起脑神经麻痹、颞叶坏死和颈脊髓病等迟发性神经系统并发症。抗凝治疗可能对视神经萎缩和脊髓型颈椎病患者有益。
Objectives: To review radiation-induced neurological complications of nasopharyngeal carcinoma (NPC). Materials & Methods: Retrospective review of patients with radiation-induced neurological complications of NPC who presented to the Neurology and Neurosurgery Departments, Tan Tock Seng Hospital in the five-year period from 1994 to 99. Results: Nine patients with 10 neurological complications were seen. Four patients had cranial nerve palsies, of whom two had optic atrophy, one had isolated third nerve lesion and another had combined third, fourth and fifth cranial nerve palsies. Three patients each had temporal lobe necrosis and cervical myelopathy. Two of the patients with temporal lobe necrosis presented with seizures while the third presented with syndrome of inappropriate anti-diuretic hormone secretion. Two patients with optic atrophy and another two with cervical myelopathy were treated with anticoagulation therapy. The patients with optic atrophy improved while the patients with cervical myelopathy stabilised. Conclusions: Radiation therapy for NPC may cause delayed neurological complications of cranial nerve palsies, temporal lobe necrosis and cervical myelopathy. Treatment with anticoagulation may be beneficial in patients with optic atrophy and cervical myelopathy.