Effects of poststroke pyrexia on stroke outcome - A meta-analysis of studies in patients
Effects of poststroke pyrexia on stroke outcome - A meta-analysis of studies in patients
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DOI：
10.1161/01.str.31.2.410
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发表时间：
2000-02-01
期刊：
影响因子：
8.3
通讯作者：
Sharma, P
中科院分区：
文献类型：
--
作者：
Hajat, C;Hajat, S;Sharma, P
背景和目的-发热对脑缺血的影响已经在动物中进行了广泛的研究。然而，在人类中，这样的研究规模很小，结果相互矛盾。我们进行了一项荟萃分析，使用所有这些发表的研究高温对中风outcome. Methods的影响，三个数据库进行了搜索所有发表的研究，研究中风发病后的温度升高和最终结果的关系。获得了组合概率值和比值比。进行异质性检验，以确保数据适用于此类分析。发病率和死亡率作为outcomemeasure.Results-Nine研究共确定了3790例患者，提供我们的研究与99%的权力，检测9%的发病率增加和84%的权力，检测发热组死亡率增加1%。死亡率的合并比值比为1.19（95% CI，0.99 - 1.43）。死亡率的异质性检验高度不显著（P>0.05），表明数据足够相似，可以进行荟萃分析。两种发病率的联合概率值均具有高度显著性（P
Background and Purpose-The effect of pyrexia on cerebral ischemia has been extensively studied in animals. In humans, however, such studies are small and the results conflicting. We undertook a meta-analysis using all such published studies on the effect of hyperthermia on stroke outcome.Methods-Three databases were searched for all published studies that examined the relationship of raised temperature after stroke onset and eventual outcome. Combined probability values and odds ratios were obtained. A heterogeneity test was performed to ensure that the data were suitable for such an analysis. Morbidity and mortality were used as outcome measures.Results-Nine studies were identified totaling 3790 patients, providing our study with 99% power to detect a 9% increase in morbidity and 84% power to detect a 1% increase in mortality for the pyrexial group. The combined odds ratio fur mortality was 1.19 (95% CI, 0.99 to 1.43). A heterogeneity test was highly nonsignificant (P>0.05) for mortality, suggesting that the data were sufficiently similar to be meta-analyzed. Combined probability values were highly significant for both morbidity (P