Staphylococcus aureus Bacteremia in Patients Infected With COVID-19: A Case Series.
Staphylococcus aureus Bacteremia in Patients Infected With COVID-19: A Case Series.
复制标题
DOI：
10.1093/ofid/ofaa518
复制
发表时间：
2020-11
影响因子：
4.2
通讯作者：
Altman DR
中科院分区：
文献类型：
--
作者：
Cusumano JA;Dupper AC;Malik Y;Gavioli EM;Banga J;Berbel Caban A;Nadkarni D;Obla A;Vasa CV;Mazo D;Altman DR
以往的病毒大流行表明，继发性细菌感染会导致较高的发病率和死亡率，金黄色葡萄球菌是主要病原体。继发性金黄色葡萄球菌菌血症对感染严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)患者死亡率的影响尚不清楚。这是一个回顾性观察病例系列，研究对象为2019年(新冠肺炎)冠状病毒病患者，他们在纽约市的两家医院发生继发性金黄色葡萄球菌菌血症。主要目的是描述新冠肺炎和金黄色葡萄球菌菌血症患者14天和30天的住院死亡率。次要终点包括新冠肺炎和金黄色葡萄球菌菌血症患者14天和30天住院死亡率的预测因素。共有42名因新冠肺炎而住院的继发性金黄色葡萄球菌菌血症患者被确认。在这些患者中，23例(54.8%)和28例(66.7%)分别在14天和30天死于首次血培养阳性。多因素分析表明，住院菌血症(入院后4天起计)和年龄是14天住院死亡率的显著预测因素，PITT菌血症评分是30天住院死亡率的显著预测因素(优势比[OR]，11.9；95%CI，2.03-114.7；P=.01；OR，1.10；95%CI，1.03-1.20；P=0.02；和OR，1.56；95%CI，1.19-2.18；P=.003)。在新冠肺炎患者中，金黄色葡萄球菌菌血症与高死亡率有关。有必要进行进一步调查，以了解新冠肺炎和继发性金黄色葡萄球菌菌血症的影响。
Previous viral pandemics have shown that secondary bacterial infections result in higher morbidity and mortality, with Staphylococcus aureus being the primary causative pathogen. The impact of secondary S. aureus bacteremia on mortality in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unknown. This was a retrospective observational case series of patients with coronavirus disease 2019 (COVID-19) who developed secondary S. aureus bacteremia across 2 New York City hospitals. The primary end point was to describe 14-day and 30-day hospital mortality rates of patients with COVID-19 and S. aureus bacteremia. Secondary end points included predictors of 14-day and 30-day hospital mortality in patients with COVID-19 and S. aureus bacteremia. A total of 42 patients hospitalized for COVID-19 with secondary S. aureus bacteremia were identified. Of these patients, 23 (54.8%) and 28 (66.7%) died at 14 days and 30 days, respectively, from their first positive blood culture. Multivariate analysis identified hospital-onset bacteremia (≥4 days from date of admission) and age as significant predictors of 14-day hospital mortality and Pitt bacteremia score as a significant predictor of 30-day hospital mortality (odds ratio [OR], 11.9; 95% CI, 2.03–114.7; P = .01; OR, 1.10; 95% CI, 1.03–1.20; P = .02; and OR, 1.56; 95% CI, 1.19–2.18; P = .003, respectively). Bacteremia with S. aureus is associated with high mortality rates in patients hospitalized with COVID-19. Further investigation is warranted to understand the impact of COVID-19 and secondary S. aureus bacteremia.
登录
查看更多内容
DOI：
10.1086/591708
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Morens DM;Taubenberger JK;Fauci AS
通讯作者：
Fauci AS
影响因子：
5.8
作者：
Kontula, Keiju S. K.;Skogberg, Kirsi;Lyytikainen, Outi
通讯作者：
Lyytikainen, Outi
影响因子：
6.4
作者：
Goncheva, Mariya, I;Conceicao, Carina;Fitzgerald, J. Ross
通讯作者：
Fitzgerald, J. Ross
影响因子：
14.2
作者：
Al-Hasan, M. N.;Lahr, B. D.;Baddour, L. M.
通讯作者：
Baddour, L. M.
影响因子：
2.1
作者：
Hill, PC;Birch, M;Morris, AJ
通讯作者：
Morris, AJ