Patterns of age-specific means and genetic variances of mortality rates predicted by the mutation-accumulation theory of ageing
Patterns of age-specific means and genetic variances of mortality rates predicted by the mutation-accumulation theory of ageing
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DOI：
10.1006/jtbi.2001.2296
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发表时间：
2001-05-07
影响因子：
2
通讯作者：
Charlesworth, B
中科院分区：
文献类型：
--
作者：
Charlesworth, B
开发了具有特定年龄有害影响的突变的通用定量遗传模型。结果表明，对于具有与年龄无关的繁殖率和外在成体死亡率的物种的最简单情况，并且没有年龄特异性突变的多效性效应，预计年龄特异性死亡率的平均遗传方差和加性遗传方差都随着年龄呈指数增长。在模型中，年龄特异性突变对死亡率具有多效性影响，这种影响要么延伸到整个成年期，要么仅限于青少年阶段，在成年期的大部分时间里，死亡率的均值和加性方差呈指数增长，从而产生平衡。然而，增长率在晚年逐渐减少，甚至可能为零。还对不同年龄之间死亡率的加性遗传相关性进行了预测。将模型的预测与人类和果蝇的数据进行比较。 (C) 2001 年学术出版社。
A general quantitative genetic model of mutations with age-specific deleterious effects is developed. It is shown that, for the simplest case of a species with age-independent reproductive rates and extrinsic adult mortality rates, and no pleiotropic effects of age-specific mutations, exponential increases with age of both the mean and additive genetic variance of age-specific mortality rates are expected. Models where age-specific mutations have pleiotropic effects on mortality that extend either throughout adult life, or are confined to juvenile stages, produce equilibria with exponential increases in the mean and additive variance of mortality rates during much of adult life. However, the rates of increase diminish late in life, and can even become zero. Predictions concerning the additive genetic correlations in mortality rates between different ages are also developed. The predictions of the models are compared with data on humans and Drosophila. (C) 2001 Academic Press.