Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
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DOI：
10.1111/acel.12706
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发表时间：
2018-04
期刊：
影响因子：
7.8
通讯作者：
Niedernhofer LJ
中科院分区：
文献类型：
--
作者：
Yousefzadeh MJ;Schafer MJ;Noren Hooten N;Atkinson EJ;Evans MK;Baker DJ;Quarles EK;Robbins PD;Ladiges WC;LeBrasseur NK;Niedernhofer LJ
生物学年龄与实际年龄的血清生物标志物将对临床护理产生重大影响。它可用于识别具有早发性虚弱或与老年相关的多病风险的个体。它也可以作为针对衰老机制的临床试验的替代终点。在这里，我们确定了MCP-1/CCL 2，一种负责招募单核细胞的趋化因子，作为生物学年龄的潜在生物标志物。在野生型（WT）小鼠中，循环单核细胞趋化蛋白-1（MCP-1）水平以年龄依赖性方式增加。在Ercc 1 −/Δ和Bubr 1 H/H早衰小鼠模型中，这种年龄依赖性增加加速。减缓Ercc 1 −/Δ和WT小鼠衰老的遗传和药物干预显著降低了血清MCP-1水平。最后，在患有主动脉瓣狭窄的老年人中，与非虚弱个体相比，虚弱个体的MCP-1水平显著较高。这些数据支持MCP-1可以作为哺乳动物生物学年龄的一种衡量标准，对延长健康衰老的干预措施有反应。
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP‐1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein‐1 (MCP‐1) levels increased in an age‐dependent manner in wild‐type (WT) mice. That age‐dependent increase was accelerated in Ercc1 −/Δ and Bubr1 H/H mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1 −/Δ and WT mice lowered serum MCP‐1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP‐1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging.
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影响因子：
64.5
作者：
Burd CE;Sorrentino JA;Clark KS;Darr DB;Krishnamurthy J;Deal AM;Bardeesy N;Castrillon DH;Beach DH;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
7.8
作者：
Dai DF;Karunadharma PP;Chiao YA;Basisty N;Crispin D;Hsieh EJ;Chen T;Gu H;Djukovic D;Raftery D;Beyer RP;MacCoss MJ;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
DOI：
10.18632/aging.100745
发表时间：
2015-05
期刊：
Aging
影响因子：
--
作者：
Brouwers B;Dalmasso B;Hatse S;Laenen A;Kenis C;Swerts E;Neven P;Smeets A;Schöffski P;Wildiers H
通讯作者：
Wildiers H