Myc and its interactors take shape.
Myc and its interactors take shape.
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DOI：
10.1016/j.bbagrm.2014.06.002
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
William B Tu;Sara Helander;Robert Pilstål;K. A. Hickman;Corey Lourenco;I. Jurisica;B. Raught;Björn Wallner;M. Sunnerhagen;L. Penn;L. Penn
中科院分区：
文献类型：
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作者：
William B Tu;Sara Helander;Robert Pilstål;K. A. Hickman;Corey Lourenco;I. Jurisica;B. Raught;Björn Wallner;M. Sunnerhagen;L. Penn;L. Penn
Myc癌蛋白是许多人类癌症发生的关键因素。因此，自三十多年前发现它以来，了解其分子活性和生物学功能一直是一个活跃的研究领域。全基因组研究表明，Myc是基因表达的全球调节者。其DNA结合伙伴蛋白Max的发现，开启了对Myc蛋白-蛋白质相互作用和蛋白质结构的广泛研究领域。在这篇综述中，我们强调了关于Myc相互作用因子和蛋白质结构的关键见解，这些见解有助于理解Myc在转录调控和癌症中的作用。Myc的结构分析显示，许多关键区域具有介导蛋白质相互作用和生物功能的瞬时结构。相互作用因子，如MAX、TRRAP和PTEF-b，提供了对Myc转录活动的机械性洞察，而其他相互作用因子，如泛素连接酶，调节Myc蛋白本身。据了解，Myc拥有一个很大的相互作用体，但许多相互作用子的功能相关性仍不清楚。在这里，我们讨论未来的研究趋势，包括在基因组范围和蛋白质组范围的方法的进展，以系统地阐明Myc的作用机制。本文是题为：MYC蛋白质在细胞生物学和病理学中的特刊的一部分。
The Myc oncoprotein is a key contributor to the development of many human cancers. As such, understanding its molecular activities and biological functions has been a field of active research since its discovery more than three decades ago. Genome-wide studies have revealed Myc to be a global regulator of gene expression. The identification of its DNA-binding partner protein, Max, launched an area of extensive research into both the protein–protein interactions and protein structure of Myc. In this review, we highlight key insights with respect to Myc interactors and protein structure that contribute to the understanding of Myc's roles in transcriptional regulation and cancer. Structural analyses of Myc show many critical regions with transient structures that mediate protein interactions and biological functions. Interactors, such as Max, TRRAP, and PTEF-b, provide mechanistic insight into Myc's transcriptional activities, while others, such as ubiquitin ligases, regulate the Myc protein itself. It is appreciated that Myc possesses a large interactome, yet the functional relevance of many interactors remains unknown. Here, we discuss future research trends that embrace advances in genome-wide and proteome-wide approaches to systematically elucidate mechanisms of Myc action. This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology.