Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.
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DOI：
10.1016/j.neuron.2016.09.006
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发表时间：
2016-09-21
期刊：
影响因子：
16.2
通讯作者：
Role LW
中科院分区：
文献类型：
--
作者：
Ballinger EC;Ananth M;Talmage DA;Role LW
最近的研究继续将胆碱能回路置于正常执行和记忆功能的中心位置，并提供了令人信服的证据，证明胆碱能信号的丧失与认知能力下降是密不可分的。本文综述了近年来有关胆碱能信号对认知相关回路活动的影响机制的研究进展。我们试图找出有争议的领域，以及共识，关于什么是已知的和不知道的中枢神经系统中的胆碱能信号如何促进正常的认知过程。此外，我们描述了最近关于胆碱能回路功能障碍在多大程度上导致与神经退行性疾病相关的认知能力下降的研究结果。
Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning, and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.