eNOS Glu298Asp polymorphism and hypertension in a cohort study in Japanese
eNOS Glu298Asp polymorphism and hypertension in a cohort study in Japanese
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DOI：
10.1016/j.ypmed.2004.03.030
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Fukumoto, S
中科院分区：
文献类型：
--
作者：
Kishimoto, T;Misawa, Y;Fukumoto, S
背景资料。近年来的病例对照研究表明，内皮型一氧化氮合酶(ENOS)基因Glu298Asp(第298位天冬氨酸替代谷氨酸)多态性与高血压病的发病呈正、负相关。为探讨内皮型一氧化氮合酶基因Glu298Asp多态是否影响高血压的发生，进行了一项回顾性队列研究。对1992年日本岛根县职工定期体检的基线资料进行回顾性队列研究，分析Glu298Asp基因多态性对1998年高血压发病的影响。Glu298Glu、Glu298Asp和Asp298Asp基因在受试者中的频率分别为86.4%、12.6%和1.1%。经单因素分析，Glu298Asp和Asp298Asp相对Glu298Glu对高血压发病率的风险比在受试者中为0.830[95%可信区间(CI)0.474~1.452]，在20~39岁受试者中为0.596(95%CI；0.207~1.717)，在40~59岁受试者中为0.915(95%CI；0.464~1.805)。经多因素分析调整性别、体重指数、血清总胆固醇、高密度脂蛋白胆固醇、空腹血糖、吸烟、饮酒习惯、饮食习惯和锻炼后，1992年Glu298Asp和Asp298Asp与Glu298Glu对高血压发病率的危险比分别为0.750(95%CI；0.421~1.335)、0.505(95%CI；0.170~1.496)和0.873(95%CI；0.434~1.757)。这些结果表明，Glu298Asp基因多态性与该人群中高血压的发病率没有关联。(C)2004年癌症预防研究所和爱思唯尔公司。保留所有权利。
Background. Some recent case-control association studies have suggested negative and positive relationship between Glu298Asp (the substitution of aspartic acid for glutamic acid at amino acid position 298) polymorphism of the endothelial nitric oxide synthase (eNOS) gene and hypertension. To investigate whether the Glu298Asp polymorphism of the eNOS gene affects the incidence of hypertension, a retrospective cohort study was performed.Methods. The baseline data among Japanese workers in Shimane Prefecture, Japan, were obtained at regular health examination in 1992, and a retrospective cohort study was performed to analyze the influence of Glu298Asp polymorphism on the incidence of hypertension in 1998.Results. The incidences of Glu298Glu, Glu298Asp, and Asp298Asp genotypes in the subjects were 86.4%, 12.6% and 1.1%, respectively. The risk ratios of Glu298Asp and Asp298Asp against Glu298Glu for the incidence of hypertension by single variance analysis were 0.830 in total subjects [95% confidence interval (CI) 0.474-1.452], 0.596 in subjects 20-39 years old (95% CI; 0.207-1.717), and 0.915 in subjects 40-59 years old (95% CI; 0.464-1.805). The risk ratios of Glu298Asp and Asp298Asp against Glu298Glu for the incidence of hypertension by multiple variance analysis adjusted for sex, BMI, serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, fasting glucose, cigarette smoking, drinking habits, eating habits, and exercise in 1992 were 0.750 in total subjects (95% CI; 0.421-1.335), 0.505 in subjects 20-39 years old (95% CI; 0.170-1.496), and 0.873 in subjects 40-59 years old (95% CI; 0.434-1.757).Conclusion. These results suggested no association between the Glu298Asp gene polymorphism and the incidence of hypertension in this selected population. (C) 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.