Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
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DOI：
10.1016/s0006-8993(01)02556-2
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发表时间：
2001-07-06
期刊：
影响因子：
2.9
通讯作者：
Anisman, H
中科院分区：
文献类型：
--
作者：
Merali, Z;Kent, P;Anisman, H
选择性地培育杏仁核兴奋性的大鼠品系（如电刺激反应的点燃率所反映的那样）在焦虑测试中也表现出差异。由于促肾上腺皮质激素释放激素 (CRH) 和铃蟾肽 (BN) 与焦虑区域水平相关，因此在捕食者暴露（雪貂）或固定后，在“慢速”和“快速”捕获中评估了这些肽以及血浆促肾上腺皮质激素（ACTH）和皮质酮的释放。雪貂暴露导致慢速大鼠血浆 ACTH 和皮质酮浓度比快速大鼠有更大的增加。相比之下。固定导致 Fast 大鼠血浆 ACTH 水平大幅上升，与该品系中观察到的剧烈挣扎相平行。在慢鼠中。应激源暴露引起下丘脑前部的 ir-BN 水平升高，正中隆起/弓状核（Me/Arc）、下丘脑室旁核（PVN）和垂体（Pit）的 ir-CRH 水平升高，而孤束核（NTS）的 ir-BN 水平降低。快速大鼠同样在 NTS 处表现出 ir-BN 减少，但与慢速大鼠不同的是，Me/Arc、PVN 和 Pit 中的 ir-CRH 因对两种应激源的反应而减少。体内微透析实验表明，与快速大鼠相比，对雪貂暴露的反应，慢速大鼠在杏仁核中央核 (CeA) 处显示出更多的 CRH 释放。然而，与慢速大鼠相比，固定在快速大鼠中引发了更明显的 CRH 释放。总而言之，结果表明这两个品系的大鼠对这些应激源表现出不同的内分泌和神经化学反应模式。 (C) 2001 年由 Elsevier Science B.V. 出版
Lines of rats selectively bred for amygdala excitability, as reflected by kindling rates in response to electrical stimulation, also exhibit differences in tests of anxiety. Inasmuch as corticotropin-releasing hormone (CRH) and bombesin (BN) have been associated with anxiety regional levels and release of these peptides, as well as plasma adrenocorticotropic hormone (ACTH) and corticosterone, were assessed in 'Slow' and 'Fast' seizing let, following predator exposure (ferret) or immobilization. Ferret exposure elicited a greater increase of plasma ACTH and corticosterone concentrations in the Slow than in the Fast rats. In contrast. immobilization provoked a greater rise of plasma ACTH levels in the Fast rats, paralleling the vigorous struggling observed in this line. In Slow rats. stressor exposure elicited increased levels of ir-BN at the anterior hypothalamus, and increased ir-CRH at the median eminence/arcuate nucleus (Me/Arc), paraventricular hypothalamic nucleus (PVN) and pituitary (Pit), whereas decreased levels of ir-BN were found at the nucleus tractus solitarius (NTS). Fast rats likewise showed decreased ir-BN at the NTS, but unlike the Slow rats, ir-CRH was reduced in the Me/Arc, PVN and Pit in response to both stressors. In vivo microdialysis experiments revealed that in response to ferret exposure, the Slow rats showed a greater CRH release at the central nucleus of the amygdala (CeA) as compared to Fast rats. However, immobilization elicited a more pronounced release of CRH in Fast than in Slow rats. Taken together, the results demonstrate that these two lines of rats show differential endocrinological and neurochemical response patterns to these stressors. (C) 2001 Published by Elsevier Science B.V.