P2X7 receptors:: Properties and relevance to CNS function
P2X7 receptors:: Properties and relevance to CNS function
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DOI：
10.1002/glia.20397
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发表时间：
2006-11-15
期刊：
影响因子：
6.2
通讯作者：
Neary, Joseph T.
中科院分区：
文献类型：
--
作者：
Duan, Shumin;Neary, Joseph T.
在由细胞外ATP激活的7个成员中，P2X(7)亚型是独一无二的，因为它可以作为阳离子通道、非选择性孔道，甚至是与多个下游成分耦合的信号复合体。在过去的十年中，P2X(7)受体在中枢神经系统细胞中发挥了多种作用，包括释放细胞因子和递质，调节突触前递质的释放，以及激活多条信号通路。尤其有趣的是，P2X(7)孔可能直接介导神经胶质细胞胞浆谷氨酸、GABA和ATP的外流，因为它提供了一种新的神经递质释放机制，不仅在生理细胞间通讯中发挥重要作用，而且在病理性神经损伤中也发挥重要作用。(C)2006年Wiley-Liss，Inc.
Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X(7) subtype is unique in that it can function as a cation channel, a nonselective pore, or even a signaling complex coupled with multiple downstream components. Several roles of P2X(7) receptors have been described in CNS cells in the past decade, including release of cytokines and transmitters, modulation of presynaptic transmitter release, and activation of multiple signaling pathways. The finding that P2X(7) pores may directly mediate efflux of cytosolic glutamate, GABA, and ATP in glial cells is particularly interesting, as it provides a novel mechanism of glial transmitter release that may play important roles not only in physiological intercellular communication but also in pathological neural injury. (c) 2006 Wiley-Liss, Inc.