Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.
Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.
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DOI：
10.3389/fnut.2016.00010
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发表时间：
2016
影响因子：
5
通讯作者：
Nagy TR
中科院分区：
文献类型：
--
作者：
Chusyd DE;Wang D;Huffman DM;Nagy TR
本综述的目的是比较和对比啮齿类动物白色脂肪垫和人类白色脂肪库的生理和代谢特征。人类脂肪分布及其代谢后果受到了广泛关注，但在转化研究中进行的大部分测试都严重依赖于啮齿动物。不幸的是，使用啮齿动物脂肪垫作为人类肥胖模型的有效性受到的关注较少。令人惊讶的是，缺乏研究证明啮齿动物和人类肥胖在肥胖相关合并症上的类似关系。因此，我们旨在比较已知的白色脂肪组织（WAT）发育和分布、两性二态性、体重减轻、脂肪因子分泌和衰老方面的异同。虽然文献支持啮齿动物和人类之间存在许多相似之处的观点，但在脂肪沉积和WAT功能方面存在显着差异。因此，有必要进行进一步的研究，以更仔细地定义啮齿动物WAT作为人类模型的优势和局限性，特别强调可比较的脂肪库，如肠系膜脂肪。
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.