Aconicatisulfonines A and B, Analgesic Zwitterionic C-20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii
Aconicatisulfonines A and B, Analgesic Zwitterionic C-20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii
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Aconicatisulfonines A 和 B，镇痛两性离子 C-20-二萜生物碱，具有来自 Aconitum carmichaelii 的重排 Atisane 骨架
DOI：
10.1021/acs.orglett.9b02479
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Shi Jiangong
中科院分区：
文献类型：
--
作者：
Wu Yuzhuo;Shao Shuai;Guo Qinglan;Xu Chengbo;Xia Huan;Zhang Tiantai;Shi Jiangong
从川乌头根的水提物中分离得到两个具有新骨架的磺化C20二萜生物碱亚胺化合物，分别命名为aconicatisulfonines A（1）和B（2）。1和2的结构通过光谱数据和量子计算以及X射线晶体学分析确定。通过阿替烷衍生物的半频哪醇重排的生物合成途径提出了1和2。化合物1和2对醋酸所致小鼠扭体反应有明显的镇痛作用。
Two sulfonated C20-diterpenoid alkaloid iminiums with a novel skeleton, named aconicatisulfonines A (1) and B (2), respectively, were isolated from a water extract of theAconitum carmichaeliilateral roots. Structures of1and2were determined by spectroscopic data and quantum calculations as well as X-ray crystallographic analysis. Biosynthetic pathways via semipinacol rearrangements of atisane derivatives are proposed for1and2. Compounds1and2exhibited remarkable analgesic activities against acetic acid-induced mice writhing.