Immunoneutralization of oxytocin attenuates preovulatory prolactin secretion during proestrus in the rat.
Immunoneutralization of oxytocin attenuates preovulatory prolactin secretion during proestrus in the rat.
复制标题
催产素的免疫中和作用减弱了大鼠发情前期的排卵前催乳素分泌。
DOI：
10.1159/000125012
复制
发表时间：
1988
影响因子：
4.1
通讯作者：
Sarkar,DK
中科院分区：
文献类型：
--
作者：
Sarkar,DK
最近的研究表明，催产素（OT）刺激垂体前叶分泌催乳素（PRL），并分泌到垂体门静脉血中的OT在大鼠发情周期中发生变化。为了更好地确定OT在生殖周期中对PRL释放的作用，研究了给予OT特异性抗血清对雌性大鼠排卵前PRL分泌的影响。在动情前期13.30和14.00 h之间给周期性雌性大鼠静脉注射OT抗血清可中和垂体门脉血中升高的OT水平，并显著降低随后的PRL峰。特征性的发情前期的促黄体生成激素（LH）的激增不受OT抗血清治疗。这些数据支持OT在生殖周期中调节PRL释放的生理作用。
Recent studies have demonstrated that oxytocin (OT) stimulates prolactin (PRL) release from the anterior pituitary gland and that the secretion of OT into pituitary portal blood changes during the rat estrous cycle. To better define the role of OT on PRL release during the reproductive cycle, the effect of administration of antiserum specific for OT on preovulatory PRL secretion in female rats was studied. Intravenous injection of OT antiserum into cyclic female rats between 13.30 and 14.00 h of proestrus neutralized the elevated levels of OT in pituitary portal blood and significantly reduced the subsequent PRL surge. The characteristic proestrous surge of luteinizing hormone (LH) was not affected by the OT antiserum treatment. These data support a physiological role for OT in the regulation of PRL release during the reproductive cycle.