Cilia in autophagy and cancer.
Cilia in autophagy and cancer.
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作者：
Cao M;Zhong Q
癌细胞与正常细胞的区别在于增殖和代谢增加、极性控制丧失以及侵入身体其他组织的可能性。作为信号转导的枢纽，初级纤毛与多种发育和退行性疾病有关。有趣的是，在多种恶性肿瘤中观察到纤毛的损失，表明纤毛在癌症发展中的潜在抑制作用。最近，新兴的研究开始揭示纤毛和自噬的双向相互作用，这是一种调节细胞稳态的基本细胞清除和再循环机制。在这里，我们总结了纤毛和自噬之间的相互作用，并讨论了纤毛在自噬和癌症中的作用。
Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental and degenerative disorders. Interestingly, loss of cilia has been observed in multiple malignant tumors, suggesting a potential suppressive role of cilia in cancer development. More recently, emerging studies began to unveil the bidirectional interaction of cilia and autophagy, a basic cellular clearance and recycling mechanism to regulate cell homeostasis. Here, we summarize the interplay between cilia and autophagy and discuss the roles of cilia in both autophagy and cancer.