Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
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DOI：
10.1016/s0920-9964(01)00404-2
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发表时间：
2002-12-01
影响因子：
4.5
通讯作者：
DeBellis, M
中科院分区：
文献类型：
--
作者：
Keshavan, MS;Dick, E;DeBellis, M
内侧颞叶和前额叶皮质的结构完整性和连通性在精神分裂症中有很好的记录，但尚不清楚它们是否代表神经病理学的病前指标。对精神分裂症（HR）高风险年轻亲属的研究为澄清这一问题提供了机会。我们在此提供的数据，从磁共振成像（MRI）研究这些结构的年轻后代的精神分裂症患者。对17例精神分裂症患者的HR子代和22例健康对照组进行了比较。使用高分辨率全脑T加权脑图像对右侧和左侧背外侧前额叶皮质（DLPFC）以及前杏仁核-海马（A-H）复合体和后杏仁核-海马（A-H）复合体进行形态测量比较。与HC组相比，HR受试者的颅内容积显著降低。调整颅内体积后，HR受试者的左前和后A-H复合体体积减少。与HC受试者相比，HR受试者还显示出前A-H复合体的显著的不对称性（右>左）。在DLPFC中未观察到显著变化。因此，左侧A-H复合体体积的偏侧改变在精神分裂症患者未受影响的年轻后代中是明显的，并且可能是神经发育起源的。后续研究需要检查这些措施的预测价值未来出现的精神分裂症的风险个人。(C)2002 Elsevier Science B. V.保留所有权利。
Abnormalities in the structural integrity and connectivity of the medial temporal and the prefrontal cortex are well documented in schizophrenia, but it is unclear if they represent premorbid indicators of neuropathology. Studies of young relatives at high-risk for schizophrenia (HR) provide an opportunity to clarify this question. We herein provide data from a magnetic resonance imaging (MRI) study of these structures in young offspring of schizophrenia patients. A series of 17 young HR offspring of schizophrenic patients were compared with 22 healthy comparison subjects (HC). Morphometric comparisons of the right and left dorsolateral prefrontal cortex (DLPFC), and the anterior and posterior amygdala-hippocampal (A-H) complex were conducted using high-resolution whole brain T, weighted brain images. Compared with the HC group, HR subjects had significant decreases in intracranial volume. The volumes of the left anterior and posterior A-H complex were reduced in the HR subjects after adjusting for intracranial volume. HR subjects also showed a significant leftward (Right > Left) asymmetry of the anterior A-H complex compared to the HC subjects. No significant changes were seen in the DLPFC. Thus, lateralized alterations in the volume of the left A-H complex are evident in unaffected young offspring of schizophrenia patients and may be of neurodevelopmental origin. Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals. (C) 2002 Elsevier Science B.V. All rights reserved.