The Evolution of PharmVar
The Evolution of PharmVar
复制标题
DOI：
10.1002/cpt.1275
复制
发表时间：
2019-01-01
影响因子：
6.7
通讯作者：
Miller, Neil A.
中科院分区：
文献类型：
--
作者：
Gaedigk, Andrea;Sangkuhl, Katrin;Miller, Neil A.
药物基因变异联盟（PharmVar）继续人类细胞色素P450 （CYP）命名数据库的使命，为临床和研究界提供药物基因变异的存储库和标准化命名法。为了提高这一资源的效用，PharmVar已经建立了一个数据库和基因专家小组，并将cyp扩展到其他临床重要的药物基因。本报告描述了从静态CYP变异表到描述药物基因变异的功能不断增长的资源的演变。
The Pharmacogene Variation Consortium (PharmVar) continues the mission of the Human Cytochrome P450 (CYP) Nomenclature database to provide the clinical and research communities a repository and standardized nomenclature of pharmacogene variation. To improve the utility of this resource, PharmVar has established a database and gene expert panels and expanded beyond CYPs to include other clinically important pharmacogenes. This report describes the evolution from static CYP variation tables to a resource with growing functionality describing pharmacogene variation.