Quantitative aspects of metabolic organization: a discussion of concepts
Quantitative aspects of metabolic organization: a discussion of concepts
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DOI：
10.1098/rstb.2000.0771
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发表时间：
2001-03-29
影响因子：
6.3
通讯作者：
Kooijman, SALM
中科院分区：
文献类型：
--
作者：
Kooijman, SALM
个体生物体的新陈代谢组织遵循简单的定量规则，这些规则可以从基本的物理化学原理中理解。动态能量收支(DEB)理论确定了这些规则，这些规则量化了个人获取和使用能量和营养的方式。该理论对亚细胞过程的新陈代谢组织提供了约束。与个体之间相互作用的规则一起，它也为理解种群和生态系统动态提供了基础。因此，该理论将生物组织的各个层面联系在一起。它适用于所有种类的生物体，并对自然历史参数的体型比例关系提供了解释，否则这些参数很难理解。相当一部分流行的经验模型被证明是DEB模型的特例，或者是非常接近的数值近似。强弱动态平衡和储备动力学的分配能力是这一理论的基石，也是理解代谢组织演化的基础。
Metabolic organization of individual organisms follows simple quantitative rules that can be understood from basic physical chemical principles. Dynamic energy budget (DEB) theory identifies these rules, which quantify how individuals acquire and use energy and nutrients. The theory provides constraints on the metabolic organization of subcellular processes. Together with rules for interaction between individuals, it also provides a basis to understand population and ecosystem dynamics. The theory, therefore, links various levels of biological organization. It applies to all species of organisms and offers explanations for body-size scaling relationships of natural history parameters that are otherwise difficult to understand. A considerable number of popular empirical models turn out to be special cases of the DEB model, or very close numerical approximations. Strong and weak homeostasis and the partition-ability of reserve kinetics are cornerstones of the theory and essential for understanding the evolution of metabolic organization.