Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
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DOI：
10.1152/physiolgenomics.00183.2007
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发表时间：
2008-01-17
影响因子：
4.6
通讯作者：
Klingenspor, M.
中科院分区：
文献类型：
--
作者：
Jastroch, M.;Withers, K. W.;Klingenspor, M.
棕色脂肪组织表达解偶联蛋白1（UCP1）是负责适应性非颤抖产热给真兽目哺乳动物的关键优势，以生存的寒冷。这种产热器官在哺乳动物进化过程中的出现仍然是未知的，因为迄今为止在有袋类动物中未能鉴定出UCP1。在这里，我们明确地确定有袋类UCP1直系同源基因的Monodelphis arbitica的基因组文库。在南美洲和澳大利亚的有袋类动物中，UCP1仅在不同的脂肪组织部位表达，并且似乎在调查中的最小物种（Sminthopsis crassicaudata）中通过冷暴露进行招募。我们的数据表明，至少在1.5亿年前就存在一种典型的棕色脂肪组织，使早期哺乳动物能够在寒冷中产生内源性热量，而不依赖于颤抖和运动活动。
Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least 150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity.