Intraneural perineurioma arising in the lateral border of the tongue.
Intraneural perineurioma arising in the lateral border of the tongue.
复制标题
神经内神经束膜瘤出现于舌外侧缘。
DOI：
10.1111/pin.12121
复制
发表时间：
2013
影响因子：
2.2
通讯作者：
Tanuma J.
中科院分区：
文献类型：
--
作者：
Hirano M;Muraki M;Nagayama M;Ehara M;Kawarada K;Suwa H;Kitano M;Tanuma J.
The term perineurioma (PN) was first suggested by Lazarus and Trombetta in 1978 to describe a rare peripheral nerve sheath tumor consisting of the proliferation of neoplastic perineurial cells. 1 It is divided into four types on the basis of histological findings: soft tissue, sclerosing, reticular and intraneural PN. Soft tissue PN generally occurs as a nodular mass subcutaneously, especially in the extremities of adults. 2 Sclerosing PN prefers the fingers of adults and reticular PN is generally observed within the upper limbs of adult women. 3, 4 Intraneural PN causes enlargement of the affected nerve, especially the thick nerves of the extremities of infants and young adults. 4 Although the etiology of this lesion is unknown, the possibility of a clonal neoplastic disorder has been supported by a previous report. 4 Intraneural PN in oral regions is extremely rare; only six cases have been reported in the literature. 5–10 This report describes an unusual case of intraneural PN in the lateral border of the tongue with histological and immunohistochemical findings. A 14-year-old boy presented at his primary dental clinic because of a painless nodule in the right lateral border of the tongue. The patient had first noticed the nodule on the surface of the tongue 2 years ago and reported that it was gradually increasing in size. He had no prior history of trauma; intraoral examination revealed an elastic, wellcircumscribed nodule on the right lateral surface of the tongue (Fig. 1a). The lesion was approximately 4× 3 mm in size, and the overlying epithelium was whitish and smooth. An excisional biopsy of the nodule was performed under local anesthesia (Fig. 1b).Histopathologically, the preparation disclosed a sessilebased and relatively well-circumscribed lesion composed of spindle-shaped cells arranged concentrically around the axons of a small peripheral nerve, forming numerous pseudo-onion bulb structures (Fig. 1c). In addition, there were many small peripheral nerves continuously from the bottom of the excisional fragment of the lesion (Fig. 1d). The pseudo-onion bulb structures consisted of a fibrous connective tissue with increased irregular collagen bundles with many capillary blood vessels and few inflammatory cells (Fig. 2a, b). Immunohistochemically, the spindle-shaped cells were positive for epithelial membrane antigen (EMA)(Fig. 2c). Glucose transporter 1 was positive within the tumor cell population, and Vimentin positivity was observed
