Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH)
复制标题
DOI：
10.1515/cclm.2001.158
复制
发表时间：
2001-10-01
影响因子：
6.8
通讯作者：
Ranke, MB
中科院分区：
文献类型：
--
作者：
Elmlinger, MW;Kühnel, W;Ranke, MB
甲状腺功能紊乱会损害儿童的正常发育。因此，我们的目的是通过使用非同位素自动化学发光免疫分析系统Immulite（R）（DPC洛杉矶，美国），建立适用于从出生到成年的血清三碘甲状腺原氨酸（T-3）游离T-3（fT（3））、甲状腺素（T-4）、游离T-4（fT（4））、甲状腺素结合球蛋白（TBG）和促甲状腺素（TSH）的参考区间。对762例甲状腺功能正常的新生儿、儿童和青少年（369例女性，393例男性;年龄1天至19岁）的血清样本进行了检查;其中381例被归类为青春期。由于非正态分布，计算了每组的第2.5、50和97.5个中位数（中心95%区间）。在出生后的前2周内，T-4 fT（4）和TSH的中位浓度高达3.2倍，而T4在出生后的第一个月内升高。各年龄组的浓度无性别差异。从1岁起，所有参数的浓度趋于下降，直到成年，除了TBG增加> 60%（p
Disorders in thyroid function can impair normal development in children. Therefore it was our aim to establish reference intervals for serum triiodothyronine (T-3) free T-3 (fT(3)), thyroxine (T-4), free T-4 (fT(4)), thyroxine binding globulin (TBG) and thyrotropin (TSH) which are applicable from birth to adulthood by using the non-isotopic automated chemiluminescence immunoassay system, Immulite (R) (DPC Los Angeles, USA). Serum samples from 762 euthyroid newborns, children and adolescents (369 female, 393 male; age 1 day to 19 years) were examined; of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (the central 95% interval) were calculated for each group. The median concentrations of T-4 fT(4), and TSH were up to 3.2-fold higher during the first 2 weeks, while T4 increased during the first month of life. The concentrations in all age groups showed no sex differences. From 1 year onwards, the concentration of all parameters tended to decrease until adult age, with the exception of TBG which increased by > 60% (p