Efficacy and Tolerability of Perampanel as Adjunctive Therapy in Chinese Patients With Focal-Onset Seizures: An Observational, Prospective Study.
Efficacy and Tolerability of Perampanel as Adjunctive Therapy in Chinese Patients With Focal-Onset Seizures: An Observational, Prospective Study.
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吡仑帕奈辅助治疗中国局灶性癫痫发作患者的疗效和耐受性：一项观察性、前瞻性研究
DOI：
10.3389/fneur.2021.731566
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发表时间：
2021
影响因子：
3.4
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Zhang R;Qiao S;Fang X;Wang K;Shi Y;Du Q;Yang T;Liu X
目的：评估吡仑帕奈（PER）辅助治疗中国局灶性癫痫发作（伴或不伴继发性全身强直阵挛性癫痫发作）患者的疗效和耐受性。方法：这项单中心前瞻性观察研究连续招募了 56 名年龄在 14-72 岁的患者。所有患者根据临床判断接受 PER 作为附加治疗。引入 PER 后 3 个月和 6 个月获得癫痫发作频率、不良事件 (AE) 和保留率。结果：3个月和6个月后的总体有效率分别为60%和71.1%，同一时间点的癫痫发作自由度分别为8%和15.8%。 3 个月随访时的保留率为 89.3%，6 个月随访时的保留率为 67.9%。不良事件的总体发生率为55.4%。报告的主要 AE 是头晕（39.3%）和嗜睡（25%）。结论：我们的研究证实了辅助 PER 在现实生活中对中国患者的疗效和耐受性。根据我们的治疗经验，中国患者需要较低的 PER 维持剂量。
Purpose: To evaluate the efficacy and tolerability of adjunctive perampanel (PER) in Chinese patients with focal-onset seizures, with or without secondarily generalized tonic-clonic seizures. Methods: Fifty-six patients aged 14–72 years were recruited consecutively in this single-center prospective observational study. All patients received PER as add-on treatment on the basis of clinical judgment. Seizure frequency, adverse events (AEs), and retention rates were obtained at 3 and 6 months after PER introduction. Results: The overall response rates were 60 and 71.1% after 3 and 6 months, respectively, and the freedom of seizures at the same points were reached in 8 and 15.8%. The retention rates were 89.3% at the 3-month follow-up and 67.9% at the 6-month follow-up. The overall incidence of adverse events was 55.4%. The leading reported AEs were dizziness (39.3%) and somnolence (25%). Conclusions: Our study confirmed the efficacy and tolerability of adjunctive PER in Chinese patients in real-life conditions. Based on our treatment experience, a lower maintenance dose of PER would be needed in Chinese patients.
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