Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker diabetic fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV
Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker diabetic fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV
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DOI：
10.1016/j.ejphar.2004.12.039
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发表时间：
2005-02-21
影响因子：
5
通讯作者：
Ahrén, D
中科院分区：
文献类型：
--
作者：
Gram, DX;Hansen, AJ;Ahrén, D
辣椒素的感觉神经脱敏已被证明可以改善Zucker糖尿病肥胖大鼠的糖尿病状况。然而，给予成年大鼠辣椒素与死亡率增加有关。因此，在本实验中，我们研究了树脂毒素（一种适用于体内使用的辣椒素的耐受类似物）对Zucker糖尿病肥胖大鼠的糖尿病状况的影响。这些大鼠单次皮下注射树脂毒素（0.01 mg/kg）可耐受，无死亡。当给药于15周龄的早期糖尿病大鼠时，树脂毒素阻止了葡萄糖稳态的进一步恶化。此外，当给予19周龄的明显糖尿病大鼠时，树脂毒素在给药后两周显著改善了葡萄糖耐量，这伴随着对口服葡萄糖的胰岛素反应增加以及二肽基肽酶IV的血浆水平降低。因此，树脂毒素是一个安全的替代辣椒素的感觉神经在实验性糖尿病中的作用的进一步调查。(C)2005 Elsevier B. V.保留所有权利。
Sensory nerve desensitization by capsaicin has been shown to improve the diabetic condition in Zucker Diabetic Fatty rats. However, administration of capsaicin to adult rats is associated with an increased mortality. Therefore, in this experiment, we examined the influence of resiniferatoxin, a tolerable analogue of capsaicin suitable for in vivo use, on the diabetic condition of Zucker Diabetic Fatty rats. A single subcutaneous injection of resiniferatoxin (0.01 mg/kg) to these rats was tolerable, with no mortality. When administered to early diabetic rats at 15 weeks of age, the further deterioration of glucose homeostasis was prevented by resiniferatoxin. Further, when administered to overtly diabetic rats at 19 weeks of age, resiniferatoxin markedly improved glucose tolerance at two weeks after administration and this was accompanied by an increased insulin response to oral glucose as well as a reduction in the plasma levels of dipeptidyl peptidase IV. Therefore, resiniferatoxin is a safe alternative to capsaicin for further investigations of the role of the sensory nerves in experimental diabetes. (C) 2005 Elsevier B.V. All rights reserved.