Reaction of Selenium Dioxide with Aromatic Ketones in the Presence of Boron Triflouride Etherate: A Protocol for the Synthesis of Triarylethanones
Reaction of Selenium Dioxide with Aromatic Ketones in the Presence of Boron Triflouride Etherate: A Protocol for the Synthesis of Triarylethanones
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DOI：
10.1021/jo201985n
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发表时间：
2012-01-06
影响因子：
3.6
通讯作者：
Myrboh, Bekington
中科院分区：
文献类型：
--
作者：
Laloo, Badaker M.;Mecadon, Hormi;Myrboh, Bekington
已经开发出一种有效的区域选择性方案，用于在二氧化硒和三氟化硼乙醚存在下，通过芳香酮与未活化芳烃的意外α，α-二芳基化来形成C-C键。通过一系列三芳基乙酮的合成证明了该方案的通用性和功能耐受性。
An efficient regioselective protocol for the C-C bond formation by the unexpected alpha,alpha-diarylation of aromatic ketones with unactivated arenes in the presence of selenium dioxide and boron trifluoride etherate has been developed. The generality and functional tolerance of this protocol is demonstrated by the synthesis of a series of triarylethanones.