Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.

Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.
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酒精研究中的内毒素:呼吁使用脂多糖挑战进行实验医学。

DOI:
10.1093/alcalc/agaa148
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发表时间:
2021
期刊:
Alcohol and alcoholism (Oxford, Oxfordshire)
影响因子:
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通讯作者:
Ray,LaraA
Ray,LaraA
中科院分区:
--
文献类型:
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作者:
Burnette,ElizabethM;Grodin,EricaN;Eisenberger,NaomiI;Ray,LaraA

文献摘要

相似文献

酒精使用障碍(AUD)炎症的研究绝大多数是临床前的,转化为临床样本是必要的。内毒素给药已成功应用于人类情绪障碍研究,为AUD研究提供了一种可翻译、可靠和安全的模型。我们主张使用内毒素挑战来阐明AUD和炎症之间的相互作用。
Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.