Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.
Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.
复制标题
酒精研究中的内毒素:呼吁使用脂多糖挑战进行实验医学。
DOI:
10.1093/alcalc/agaa148
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发表时间:
2021
期刊:
影响因子:
--
通讯作者:
Ray,LaraA
中科院分区:
文献类型:
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作者:
Burnette,ElizabethM;Grodin,EricaN;Eisenberger,NaomiI;Ray,LaraA
Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.