Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic
Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic
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使用自体生长因子凝胶和多孔可吸收陶瓷进行脊柱融合
DOI：
10.1007/s00586-003-0597-9
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发表时间：
2004
影响因子：
2.8
通讯作者：
R. Gillies
中科院分区：
文献类型：
--
作者：
W. Walsh;A. Loefler;S. Nicklin;D. Arm;R. Stanford;Yan Yu;Richard I. Harris;R. Gillies
通过单一应用外源性生长因子或骨形态发生蛋白来促进愈合并不是一个新概念。通过分离和浓缩血小板，使用自体生长因子为愈合部位提供多种内源性生长因子。采用老年绵羊(5~6岁母羊)后外侧融合模型，观察通过自体血小板分离添加生长因子对可吸收珊瑚骨替代物融合的生物力学和组织学特性的影响。在6个月时，Pro Osteon500R加上抽吸骨髓的自体生长因子的组合导致了最大的弯曲刚度，但不是极限载荷。自体生长因子可以从血小板中分离出来，并进行浓缩，为融合部位提供多种生长因子，以帮助脊柱融合。
Augmenting healing through a single application of an exogenous growth factor or bone morphogenetic protein is not a new concept. The use of autologous growth factors through platelet isolation and concentration provides multiple endogenous growth factors to the healing site. A posterolateral fusion model in aged sheep (5- to 6-year-old ewes) was used to examine the effects of the addition of growth factors through autologous platelet isolation on the biomechanic and histologic properties of the fusion using a resorbable coral bone graft substitute. At 6 months the combination of autologous growth factors to the Pro Osteon 500R plus aspirated bone marrow resulted in the greatest bending stiffness but not ultimate load. Autologous growth factors can be isolated from platelets and concentrated to provide multiple growth factors to the fusion site to aid in spinal fusion.
生长因子对骨细胞复制和分化的影响。
影响因子：
4.2
作者：
Canalis,E
通讯作者：
Canalis,E