Reye's syndrome and aspirin. Evidence for a dose-response effect.
Reye's syndrome and aspirin. Evidence for a dose-response effect.
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雷氏综合症和阿司匹林。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
W. Gunn
中科院分区：
文献类型：
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作者：
P. Pinsky;E. Hurwitz;L. Schonberger;W. Gunn
从公共卫生服务的Reye综合征和药物的主要研究收集的数据进行了分析，以评估Reye综合征的发展和阿司匹林的剂量之间的关系，在前期呼吸道或水痘疾病。在暴露于阿司匹林的患者中，发现病例患者在发病前4天接受的阿司匹林平均日剂量和最大日剂量以及阿司匹林剂量（中位数分别为25.1 mg/kg、33.0 mg/kg和65.4 mg/kg）均高于对照组（中位数分别为14.5 mg/kg、19.0 mg/kg和27.0 mg/kg）。与增加阿司匹林剂量相关的过度风险主要是由于中等剂量水平（例如，15至27 mg/kg/天），而不是更高水平（大于27 mg/kg/天）。暴露病例患者和对照组之间的剂量差异在发病前第3天和第4天最大。
Data collected from the Public Health Service Main Study of Reye's Syndrome and Medications were analyzed to assess the relationship between the development of Reye's syndrome and the dose of aspirin received during the antecedent respiratory or chickenpox illness. Among those exposed to aspirin, case-patients were found to have received greater average daily and maximum daily doses of aspirin and greater doses of aspirin on the first four days of the antecedent illness (median, 25.1 mg/kg; 33.0 mg/kg; and 65.4 mg/kg; respectively) than did controls (median, 14.5 mg/kg; 19.0 mg/kg; and 27.0 mg/kg; respectively). The excess risk associated with increasing aspirin doses was due primarily to intermediate levels of dose (eg, 15 to 27 mg/kg per day) rather than higher levels (greater than 27 mg/kg per day). The dose difference between exposed case-patients and controls was greatest on days 3 and 4 of the antecedent illness.
阿司匹林是雷氏综合症的危险因素。
DOI：
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发表时间：
1982
期刊：
JAMA : the journal of the American Medical Association
影响因子：
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作者：
Waldman,RJ;Hall,WN;McGee,H;VanAmburg,G
通讯作者：
VanAmburg,G