Prognostic Value of the Modified Glasgow Prognostic Score in Patients Undergoing Radical Surgery for Hepatocellular Carcinoma.
Prognostic Value of the Modified Glasgow Prognostic Score in Patients Undergoing Radical Surgery for Hepatocellular Carcinoma.
复制标题
改良格拉斯哥预后评分对接受肝细胞癌根治手术的患者的预后价值。
DOI：
10.1097/md.0000000000001486
复制
发表时间：
2015-09
期刊：
影响因子：
1.6
通讯作者：
Qiu SJ
中科院分区：
文献类型：
--
作者：
Ni XC;Yi Y;Fu YP;He HW;Cai XY;Wang JX;Zhou J;Cheng YF;Jin JJ;Fan J;Qiu SJ
补充数字内容可在文本中找到。越来越多的一致证据表明，全身炎症与肝细胞癌 (HCC) 患者预后不良之间存在关联。本研究的目的是为接受肝切除术的 HCC 患者确定一种基于炎症的优质预后评分系统。我们分析了两个独立队列，共 723 名在 2010 年至 2012 年间接受根治性手术的 HCC 患者。炎症评分的预后价值，包括格拉斯哥预后评分 (GPS)、改良 GPS (mGPS)、中性粒细胞与淋巴细胞比率、血小板淋巴细胞比率、预后指数和预后营养指数，以及巴塞罗那诊所肝癌和肝癌意大利计划分期系统在 367 名患者的测试队列中进行了分析，并在 356 名患者的验证队列中进行了验证。 mGPS 的高分与肿瘤尺寸大、血管侵犯和晚期临床分期相关。多变量分析表明，mGPS 与总生存期和无病生存期独立相关，并且与其他基于炎症的评分相比，具有更高的曲线下面积值。这项研究的结果表明，mGPS 是可切除 HCC 患者预后不良的独立标志，并且优于其他基于炎症的评分。
Supplemental Digital Content is available in the text There is increasing and consistent evidence concerning the association of systemic inflammation and poor outcome in patients with hepatocellular carcinoma (HCC). The aim of this study was to identify a superior inflammation-based prognostic scoring system for patients with HCC undergoing hepatectomy. We analyzed two independent cohorts of a total of 723 patients with HCC who underwent radical surgery between 2010 and 2012. The prognostic value of the inflammation scores, including the Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio, platelet lymphocyte ratio, prognostic index, and prognostic nutritional index, as well as the Barcelona Clinic Liver Cancer and Cancer of the Liver Italian Program staging systems was analyzed in a test cohort of 367 patients and validated in a validation cohort of 356 patients. A high score with the mGPS was associated with large tumor size, vascular invasion, and advanced clinical stage. Multivariate analysis showed that the mGPS was independently associated with overall survival and disease-free survival, and had a higher area under the curve value in comparison with other inflammation-based scores. The results of this study demonstrated that the mGPS is an independent marker of poor prognosis in patients with resectable HCC and is superior to other inflammation-based scores.