Ventilatory effects and interactions with change in PaO2 in awake goats.
Ventilatory effects and interactions with change in PaO2 in awake goats.
复制标题
清醒山羊的通气效应及其与 PaO2 变化的相互作用。
DOI：
10.1152/jappl.1991.71.4.1254
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Bisgard,GE
中科院分区：
文献类型：
--
作者：
Daristotle,L;Engwall,MJ;Niu,WZ;Bisgard,GE
我们利用选择性颈动脉体（CB）灌注同时改变动脉异氧血症中激发的O2分数来表征清醒山羊对动脉PO2 （PaO2）变化的非CB化学受体通气反应，并确定不同水平的CB PO2对这种反应的影响。全体性高氧（PaO2大于400 Torr）显著提高了CB常氧状态下山羊的吸气通气量（VI）和潮气量（VT），全体性低氧（PaO2 = 29 Torr）显著提高了山羊的吸气通气量（VI）和呼吸频率。全身缺氧时CB缺氧（CB PO2 = 34 Torr）可显著提高VI、VT和VT/TI；肺泡缺氧的通气效果不受全身PaO2变化的影响。我们得出结论，在CB常氧状态下，通气受到全身缺氧和高氧的刺激，并且这种对全身O2变化的通气反应以一种累加的方式影响CB O2反应。
We utilized selective carotid body (CB) perfusion while changing inspired O2 fraction in arterial isocapnia to characterize the non-CB chemoreceptor ventilatory response to changes in arterial PO2 (PaO2) in awake goats and to define the effect of varying levels of CB PO2 on this response. Systemic hyperoxia (PaO2 greater than 400 Torr) significantly increased inspired ventilation (VI) and tidal volume (VT) in goats during CB normoxia, and systemic hypoxia (PaO2 = 29 Torr) significantly increased VI and respiratory frequency in these goats. CB hypoxia (CB PO2 = 34 Torr) in systemic normoxia significantly increased VI, VT, and VT/TI; the ventilatory effects of CB hypoxia were not significantly altered by varying systemic PaO2. We conclude that ventilation is stimulated by systemic hypoxia and hyperoxia in CB normoxia and that this ventilatory response to changes in systemic O2 affects the CB O2 response in an additive manner.